The biguanide concentration of polyhexamethylene biguanide hydrochloride (PHMB-HCl) was measured by non-aqueous titration with HClO4, argentometric titration, the Kjeldhal method, and colloidal titration. The summation value of non-aqueous titration and argentometric titration corresponded to two titrable nitrogens in five nitrogens per one unit of PHMB-HCl, and consisted with the result of the...

Infected wounds are still one of the great challenges in medicine. In the last decade, it has become increasingly clear that antimicrobial chemotherapy is limited by the spread of antimicrobial resistance. Fortunately, new, highly effective antiseptic substances with a broad antimicrobial spectrum are available, so local treatment is expected to get increasingly more important in wound therapy....

AIMS To report the clinical and diagnostic findings of a patient with Acanthamoeba keratitis resistant to both polyhexamethylene biguanide (PHMB)-hexamidine and chlorhexidine-hexamidine treatment. METHODS Slit-lamp biomicroscopy, corneal cell scraping and histopathology were performed on a 39-year-old woman presenting with corneal ulcer in her left eye. RESULTS The patient was successfully ...

Prophylactic mupirocin for peritoneal catheter exit sites reduces exit site infection (ESI) risk but engenders antibiotic resistance. We present early interim safety analysis of an open-label randomized study comparing polyhexamethylene biguanide (PHMB) and mupirocin. A total of 106 patients randomized to 53 in each group were followed up for a mean of 12.68 months per patient. On safety analys...

Dear Editor, Acanthamoeba species are opportunistic pathogens that can cause life-threatening diseases in the immunocompromised host. In healthy individuals, Acanthamoeba can cause ulcerating keratitis, which is associated with the use of improperly sterilised contact lenses, trauma or washing with contaminated water.1 Reports have shown that the defenses of a healthy host seemed sufficient to ...

Many synthetic compounds have been applied to impart antimicrobial properties fabrics. In this review, the types of bacteria are described. Furthermore, agents, namely quaternary ammonium (QACs), polyhexamethylene biguanide (PHMB), triclosan, and nitrogen-halamines (N-halamines), discussed along with their properties, advantages disadvantages. Although agents neutralise microorganisms, some adv...

Polyhexamethylene biguanide (PHMB; CAS no. 2875743-3) is a preservative used as a biocide in industrial products (e.g. swimming pool disinfectants), medical devices (e.g. wound cleansers), contact lens solutions, and cosmetics such as wet wipes, deodorants, and facial cleansers. It is considered to be a rare contact allergen, with a sensitization rate of ∼0.5% in an unselected population (1, 2)...