Nine human disorders result from the toxic accumulation and aggregation of proteins with expansions in their endogenous polyalanine (polyA) tracts. Given the prevalence of polyA tracts in eukaryotic proteomes, we wanted to understand the generality of polyA-expansion cytotoxicity by using yeast as a model organism. In our initial case, we expanded the polyA tract within the native yeast poly(Ad...

Polyglutamine (polyQ) tracts have been studied extensively for their roles in a number of human diseases such as Huntington’s or different Ataxias. However, it has also been recognized that polyQ tracts are abundant and may have important functional and evolutionary roles. Especially the association of polyQ and also polyalanine (polyA) tracts with transcription factors and their activation act...

Using non-radioactive in situ hybridization we studied the expression of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and PolyA+ RNA in psoriasis and normal skin, and GAPDH in epidermis following application of a range of noxious stimuli, including ultraviolet radiation, Sellotape stripping and various irritants. In keeping with what might have been expected from previous results on cell cu...

MOTIVATION Pre-mRNA cleavage and polyadenylation are essential steps for 3'-end maturation and subsequent stability and degradation of mRNAs. This process is highly controlled by cis-regulatory elements surrounding the cleavage/polyadenylation sites (polyA sites), which are frequently constrained by sequence content and position. More than 50% of human transcripts have multiple functional polyA...

Tujuan penelitian ini untuk menganalisis kemampuan pemecahan masalah matematis siswa dalam menyelesaikan soal segiempat dan segitiga. Penelitian menggunakan jenis kualitatif deskriftif. dilaksanakan pada semester genap Tahun ajaran 2019/2020 di SMPN 1 Lemahabang. Subjek adalah kelas VII-F yang berjumlah 29 siswa, subjek dipilih berdasarkan teknik purposive sampling pertimbangan. Data diperoleh ...

In Belgian Malinois dogs, a 38-base pair variable number tandem repeat in the dopamine transporter gene (SLC6A3) is associated with behavior changes in Malinois. By additional sequencing in SLC6A3, we identified an intronic 12-nucleotide poly(A) insertion ("PolyA(22)") before the terminal exon that was associated with seizure, "glazing over" behaviors, and episodic biting behaviors in a sample ...

We develop extensions of the Polya posterior that can be used to estimate population quantiles in stratified populations. In the simple case with no auxiliary information, estimates based on this extension to the Polya posterior perform similarly to the standard frequentist estimates. The Polya posterior can be extended to incorporate a variety of prior knowledge about an auxiliary characterist...

This thesis introduces a model for epidemics on networks based on the classical Polya process. Temporal contagion processes are generated on the network nodes using a modified Polya sampling scheme that accounts for spatial infection among neighbouring nodes. The stochastic properties and asymptotic behaviour of the resulting network Polya contagion process are analyzed. Given the complicated n...

A network epidemics model based on the classical Polya urn scheme is investigated. Temporal contagion processes are generated on the network nodes using a modified Polya sampling scheme that accounts for spatial infection among neighbouring nodes. The stochastic properties and the asymptotic behaviour of the resulting network contagion process are analyzed. Unlike the classical Polya process, t...