Uniaxial tensile experiments were performed on pig skin to investigate the tensile stressestrain response at both quasi-static and dynamic rates of deformation. A Kolsky tension bar, also called a split Hopkinson tension bar (SHTB), was modified to conduct the dynamic experiments. Semiconductor strain gages were used to measure the low levels of the transmitted signal from pig skin. A pulse sha...

The successful transplantation of autologous and isologous tissue has been achieved for many years. However, the ability of an adult host animal to reject a homograft from another adult animal of a different strain within the same species has prevented successful homotransplantation in adult animals. As early as 1953 Billingham and Sparrow' demonstrated that living donor epidermal cells treated...

Metabolism of chemicals occurs in skin and therefore should be taken into account when one determines topical exposure dose. Skin metabolism is difficult to measure in vivo because biological specimens may also contain metabolites from other tissues. Metabolism in skin during percutaneous absorption can be studied with viable skin in flow-through diffusion cells. Several compounds metabolized b...

The oncolytic properties of a new Clostridium strain 01 originating from pig skin extracts have been studied. The specificity toward various animal tumors of a typical pig skin fraction, spore-containing punctates of lysing tumors, and pure spore suspensions proved to be comparable. Several different kinds of transplanted tumors can be destroyed. The activity against spontaneous or induced tumo...

A guinea pig skin assay was developed as a measure of ileal loop fluid-inducing factor in the rabbit and possibly of the causative principle of Bacillus cereus food poisoning. A green or bloody necrotic reaction was produced in the guinea pig skin by injection of culture filtrates from 21 of 24 B. cereus strains tested, and by no other Bacillus species tested except for the closely related B. t...

The permeability characteristics of newborn pig skin and adult rat skin, either fresh or stored, to model drugs were examined and compared. Special attention was paid to the design to a new experimental system suitable for evaluation of skin permeability to various substances. Two types of model substances were used; insulin, a poorly absorbable substance with high molecular weight as a represe...

Passive anaphylaxis of the guinea pig has been subjected to numerous immunological studies (1). They have established for both systemic (2) and cutaneous anaphylaxis (3) the levels of specific antibody required, and the need for a latent period of sensitization (4, 5) which is generally believed to be the time required for the binding of the antibody to tissue receptors. Further evidence for an...

Passive anaphylaxis of the guinea pig has been subjected to numerous immunological studies (1). They have established for both systemic (2) and cutaneous anaphylaxis (3) the levels of specific antibody required, and the need for a latent period of sensitization (4, 5) which is generally believed to be the time required for the binding of the antibody to tissue receptors. Further evidence for an...