Biosynthetic strategies for the production of recombinant elastin-like protein (ELP) triblock copolymers have resulted in elastomeric protein hydrogels, formed through rapid physical crosslinking upon warming of concentrated solutions. However, the strength of physically crosslinked networks can be limited, and options for non-toxic chemical crosslinking of these networks are not optimal. In th...

Physical properties of scaffolds intended for myocardial tissue regeneration were studied. Mechanical properties and degradation rates were evaluated for degradable scaffolds composed of poly (2-hydroxyethyl methacrylate) (pHEMA) crosslinked with polycaprolactone (PCL). pHEMA copolymerized with tetraethylene glycol as a crosslinker served as a control. Fibroblast cells were used for cytotoxicit...

High temperature shape memory polymers that can withstand the harsh temperatures for durable applications are synthesized, and the aromatic polyimide chains with flexible linkages within the backbone act as reversible phase. High molecular weight (Mn) is demanded to form physical crosslinks as fixed phase of thermoplastic shape memory polyimide, and the relationship between Mn and glass transit...

© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim 1 wileyonlinelibrary.com in a shear-thinning, physical hydrogel can provide mechanical protection that prevents cell membrane damage during injection. [ 8 ] Weak hydrogels with shear moduli < 50 Pa were previously found to offer the best protection; however, these materials typically biodegrade too quickly (within 1–2 weeks) to support long-term...

PURPOSE The present study deals with evaluation of crosslinked poly vinyl alcohol (PVA) as a potential disintegrant. METHODS Crosslinking of PVA was carried out using glutaraldehyde as a crosslinker, in presence of acidic conditions. The crosslinking reaction was optimized for a) polymer: crosslinker ratio; b) temperature requirement and c) reaction duration. Certain physical parameters of th...

Collagen is extensively used in fabrication of hydrogels for biomedical applications but needs improvement after its isolation from tissues due to slow gelation and poor mechanical properties. Crosslinking could tailor such has previously been crosslinked by chemical or photochemical methods. Chemical crosslinkers are often toxic, the crosslinking reaction difficult control. Photochemical usual...

Innovative hydrogels obtained by physical and chemical crosslinking of deacylated Gellan gum have been characterized in terms of water uptake, rheological properties and compressibility, and the behaviour of the tested materials, according to the type of the obtained network, is thoroughly discussed. The release from the various gels of loaded model molecules of different steric hindrance was a...

Gelatin is one of the most popular natural polymers which widely used in food, pharmaceutical, biomedical and cosmetic industries. The gelatin has been prepared from different sources such as porcine skin, cattle bone, fish, etc. Depending on type acidic alkali extraction processes A B were obtained. This chapter provides a comprehensive overview preparation base hydrogel. Furthermore, we evalu...

Microbial transglutaminase (mTGase) crosslinking is a useful method for significantly improving the physical functionality of proteins. This study focused on the effect of mTGase modification on the functional properties of yak and cow caseins, including solubility, emulsifying property, water and oil absorption capacity, foaming property, and stability in the presence of Na, Ca, and Mg. The re...