Tablet manufacturing provides quite a good example and is also the process where many pharmaceutical companies are choosing to pilot continuous manufacturing. In a traditional batch approach, tablet manufacturing is really a series of disconnected single unit operations, installed in separate rooms, with product waiting to be released to the next process step in another room. The equipment is i...

Phenytoin (pulverized powder), mefenamic acid (capsule), and sulpiride (film-coated tablet) are currently available on the Japanese market. For absorption of these drugs from their pharmaceutical preparations, they must disintegrate and dissolve during passage through the gastrointestinal tract. The bioavailability of these drugs differ among different pharmaceutical preparations and even for t...

Novel strategies are required to manufacture customized oral solid dosage forms for personalized medicine applications. 3D Pharming, the direct printing of pharmaceutical tablets, is an attractive strategy, since it allows for the rapid production of solid dosage forms containing custom drug dosages. This study reports on the design and characterization of a biocompatible photocurable pharmaceu...

In modern clinical practice, combination fixed - dose tablets have become a baseline foreffective therapy in many clinical conditions. The Hydrochlorothiazide (Hctz) (12.5mg) /Lisinopril (Lis) (10 mg) tablet is a combination drug for treatment of hypertension. In thisstudy, the tablets were prepared by wet granulation method and characterized in terms of weightvariation, hardness, friability, d...

The research includes, spectrophotometric determination for Metronidazole drug (MND) in pharmaceutical form (tablet), using multi-wavelengths technique, the results obeyed Beer’s law concentration ranges of between (0.5-25 µg.ml-1), recovery percentage Rec% (99.99- 100.05), RSD% (0.0011-0.0019), and detection limit (0.2042-2.9772 µg.ml-1) This method been successfully applied to MND tablet. als...

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OBJECTIVES Electronic detailing (e-detailing), the use of electronic devices to facilitate sales presentations to physicians, has been adopted and expanded in the pharmaceutical industry. To maximize the potential outcome of e-detailing, it is important to understand medical representatives (MRs)' behavior and attitude to e-detailing. This study investigates how information technology devices s...

Tablet dissolution is strongly affected by swelling and solvent penetration into its matrix. A terahertz-pulsed imaging (TPI) technique, in reflection mode, is introduced as a new tool to measure one-dimensional swelling and solvent ingress in flat-faced pharmaceutical compacts exposed to dissolution medium from one face of the tablet. The technique was demonstrated on three tableting excipient...

An increasing interest in the use of natural polymers or gums in pharmaceutical formulations focusing the tremendous orientation to discover and extract such gums. The pharmaceutical industry is ever thirsty to satisfy patient’s therapeutic needs by utilizing inactive excipients along with active ingredients in formulation development. Binders are added to tablet formulations to add cohesivenes...

Traditional pharmaceutical dissolution tests determine the amount of drug dissolved over time by measuring drug content in the dissolution medium. This method provides little direct information about what is happening on the surface of the dissolving tablet. As the tablet surface composition and structure can change during dissolution, it is essential to monitor it during dissolution testing. I...