OBJECTIVE To determine the association between oxidative stress parameters with periodontal disease, bleeding, and the presence of different periodontal bacteria. METHODS A cross-sectional study in a sample of eighty-six patients, divided into three groups depending on their periodontal status. Thirty-three with chronic periodontitis, sixteen with gingivitis, and thirty-seven with periodontal...

Onset of chronic periodontitis is associated with an aberrant polymicrobial community, termed dysbiosis. Findings regarding its etiology obtained using high-throughput sequencing technique suggested that dysbiosis holds a conserved metabolic signature as an emergent property. The purpose of this study was to identify robust biomarkers for periodontal inflammation severity. Furthermore, we inves...

Periodontal disease is a bacteria-induced chronic inflammatory disease affecting the soft and hard supporting structures encompassing the teeth. When left untreated, the ultimate outcome is alveolar bone loss and exfoliation of the involved teeth. Traditional periodontal diagnostic methods include assessment of clinical parameters and radiographs. Though efficient, these conventional techniques...

atherosclerosis is the most common cause of myocardial infarction and ischemic stroke. various risk factors have been identified for atherosclerosis. recently, bacterial and viral organisms, which are involved in chronic inflammatory processes, have been also implicated in atherosclerosis development. individuals with a prior history of periodontal diseases and/or tooth loss are considered to be...

Nowadays there is increasing interest in identifying-and using-metabolites that can be employed as biomarkers for diagnosing, treating and monitoring diseases. Saliva and NMR have been widely used for this purpose as they are fast and inexpensive methods. This case-control study aimed to find biomarkers that could be related to glioblastoma (GBL) and periodontal disease (PD) and studied a possi...

Periodontal disease is characterized by inflammation and bone loss. The balance between inflammatory mediators and their counter-regulatory molecules may be fundamental for determining the outcome of the immune pathology of periodontal disease. Transforming growth factor-β (TGF-β) and vascular endothelial growth factor (VEGF) represent a family of polypeptide proteins involved in the inflammati...

Recent studies suggest that periodontal disease and type 2 diabetes mellitus are bi-directionally associated. Identification of a molecular signature for periodontitis using unbiased metabolic profiling could allow identification of biomarkers to assist in the diagnosis and monitoring of both diabetes and periodontal disease. This cross-sectional study identified plasma and salivary metabolic p...

background: considering the role of matrix metalloproteinase-3 (mmp-3) and tissue inhibitor of matrix metalloproteinase-1 (timp-1) in the pathogenesis of periodontitis, the present study is to estimate the levels of mmp-3 and timp-1 in gingival crevicular fluid (gcf) in periodontal health, disease and to evaluate the effect of periodontal therapy on mmp-3 and timp-1 concentrations in gcf. mater...

background :   a  lot  of  studies  have  shown  periodontal  diseases  as  a  risk  factor  for  adverse  pregnancy  out­comes. the  as­sociation  between  periodontitis  and  preeclampsia  has  been  studied  recently  with  contro­versy. considering  the  importance  of  preventing  preeclampsia  as  a  dangerous  and  life-threatening  disease  in  pregnant  women,  the  pre­sent  study  wa...