The use of the quantitative nasal culture was investigated as a means of evaluation of new antimicrobial drugs in man. Cyclacillin was somewhat more active in vitro than penicillin G against penicillin G-resistant organisms. Cyclacillin was highly effective in suppressing staphylococci susceptible to penicillin G in nasal carriers but did not suppress staphylococci resistant to penicillin G. Al...

the most accepted method of secondary prophylaxis in rheumatic fever (rf) has been an injection of 1,200,000 units of benzathine penicillin g (bpg) every 4 weeks, but recurrences have been reported in some patients despite such a prophylaxis program. the who recommended bpg injections every 3 weeks in high risk patients and situations due to some published data in favor of inadequacy of once ev...

Military Special Forces trainees undergo intense psychological and physical stressors that often lead to respiratory infection. During 1998-2000, 477 Navy Special Forces trainees were enrolled in a double-blind trial of oral azithromycin (1 g given weekly) plus a placebo injection, compared with benzathine penicillin G (1.2 million U) plus azithromycin placebo tablets. Among the 464 subjects wi...

BACKGROUND Pilot studies suggest that a single, 2-g oral dose of azithromycin may be an alternative to a 2.4-MU intramuscular dose of penicillin G benzathine in the prevention and treatment of syphilis. We evaluated the efficacy of treatment with azithromycin in a developing country. METHODS A total of 328 subjects, 25 with primary and 303 with high-titer (a titer of at least 1:8 on a rapid p...

Roxithromycin (RU 965), a new macrolide antibiotic, was shown to be effective for therapy of active syphilis in rabbits. Dark-field-positive lesions were produced in adult male rabbits by intradermal inoculation of approximately 10(6) Treponema pallidum organisms at each of 11 sites. Beginning 7 days after infection, six animals per group were treated with benzathine penicillin G (200,000 U, in...

Doxycycline is the preferred recommended second-line treatment for the treatment of early syphilis. Recent reports showed a declining efficacy trend of doxycycline in treatment of early syphilis. The aim of our study was to assess the serological response to the treatment for early syphilis with doxycycline compared with benzathine penicillin G and evaluate whether doxycycline is still an effec...

PURPOSE Patients with a history of allergic reaction to penicillin, but with no detectable specific IgE, are common and pose a dilemma. Challenge tests are considered to be the diagnostic gold standard. The aim of this study was to identify subgroups of patients with very low risk for reactions who could be safely tested using a more rapid and simple procedure. METHODS A total of 580 consecut...

During a study of the serum levels of penicillin necessary for the prophylaxis of rheumatic fever in children (Carron, Maillard, and Pellerat, 1961) we made some observations which could have practical importance in the treatment of syphilis. We observed certain variations in the serum levels after the administration of benzathine penicillin some of which appeared to be rather paradoxical. In g...

It is now almost 30 years since penicillin was introduced to combat the endemic treponematoses of childhood, prevalent in rural areas of many developing countries. Preparations such as PAM and benzathine penicillin were shown to produce effective blood and tissue concentrations of 4 days' to 3 weeks' duration after single intramuscular injections. Long-acting treatment thus became available whi...

The cases are reported of two patients with chronic Lyme arthritis resistant to the recommended antibiotic regimens who were cured by long term treatment with benzathine penicillin. It is suggested that the sustained therapeutic levels of penicillin were effective either by the inhibition of germ replication or by lysis of the spirochaetes when they were leaving their sanctuaries.