UNLABELLED Background Primary mediastinal large B-cell lymphoma is a rare lymphoma accounting for no more than 3% of all B-cell lymphomas in children and adolescents. However, patients in this young age group with this lymphoma have the shortest event-free survival of patients with any B-cell lymphoma under current standard chemotherapy protocols. Lymphomas with features intermediate between pr...

Over the past century, classical Hodgkin lymphoma (HL) has been transformed from a uniformly fatal disease to one of most curable cancers. Given high cure rate, major focus HL management is reducing use radiation therapy (RT) and chemotherapy agents such as procarbazine doxorubicin minimize long-term toxicities. In both North America Europe, an important philosophy in guide intensity treatment ...

At the time of writing, five anti-CD19 CAR T-cell products are approved by U.S. Food and Drug Administration for seven different indications in lymphoid malignancies, including B-cell non-Hodgkin lymphoma, pediatric acute lymphoblastic leukemia, multiple myeloma. T cells chronic lymphocytic myeloid less common malignancies such as lymphomas Hodgkin lymphoma being tested early-phase clinical tri...

PURPOSE AND EXPERIMENTAL DESIGN The role of RASSF1A has been elucidated recently in regulating apoptosis and cell cycle progression by inhibiting cyclin D1 accumulation. Aberrant RASSF1A promoter methylation has been found frequently in multiple adult cancer types. Using methylation-specific PCR and reverse transcription-PCR, we investigated epigenetic deregulation of RASSF1A in primary tumors,...

Pediatric follicular lymphoma is a rare disease that differs genetically and clinically from its adult counterpart. With the exception of pediatric follicular lymphoma with IRF4-translocation, the genetic events associated with these lymphomas have not yet been defined. We applied array-comparative genomic hybridization and molecular inversion probe assay analyses to formalin-fixed paraffin-emb...

Lymphoma may affect the ureter in cases of retroperitoneal involvement. We present a case of an adolescent male found to have non-Hodgkin lymphoma initially presenting as ureteral stricture evident on imaging. He was treated and responded to multiagent chemotherapy with resolution of both the lymphoma and the ureteral stricture. Although rare, non-Hodgkin lymphoma should be included in the diff...

Un enfant de 12 ans atteint d'un lymphome medias­tinal a ete hospitalise pour des manifestations neurolo­giques comportant: facies myasthenique, douleurs radi­culaires intenses, amyotrophie et diminution de la force musculaire au niveau des membres.  A l'examen du liquide cephalo-rachidien, ii existait une meningite neoplasique. Celle-ci a ete traitee par le methotraxate intra-rachidien parall...