Rajavelu P, Rayapudi M, Moffitt M, Mishra A, Mishra A. Significance of para-esophageal lymph nodes in food or aeroallergeninduced iNKT cell-mediated experimental eosinophilic esophagitis. Am J Physiol Gastrointest Liver Physiol 302: G645–G654, 2012. First published December 29, 2011; doi:10.1152/ajpgi.00223.2011.—Eosinophilic esophagitis (EoE) is a recently recognized inflammatory disorder driv...

We report 8 infants with immediate hypersensitivity reactions to foods (milk, egg, or peanut), occurring at the first-known exposure. Each developed symptoms within the first hour, but these generally settled within 2 hours. Sensitisation to the food concerned was demonstrated by positive immediate allergen skin prick tests in every case. Symptoms experienced included irritability, erythematous...

The effector immune mechanisms underlying peanut-induced anaphylaxis remain to be fully elucidated. We investigated the relative contribution of Igs, mast cells (MCs), and FcepsilonRI in the elicitation of anaphylaxis in a murine model. Assessment of peanut hypersensitivity reactions was performed clinically and biologically. Our data show that wild-type (WT; C57BL/6 strain) mice consistently d...

BACKGROUND No longitudinal studies exist on the natural history of food hypersensitivity and IgE sensitisation to food allergens in adults. OBJECTIVE To examine the natural history of food hypersensitivity, the natural history of IgE sensitisation to food allergens and to investigate the risk factors for new onset food hypersensitivity. METHODS Food hypersensitivity was questionnaire-assess...

The rising prevalence of food allergies poses an BLOCKINincreasingly BLOCKINimportant BLOCKINclinical BLOCKINproblem. BLOCKINPeanut is one of the most potent allergens, and allergic reactions to peanuts may even be fatal. BLOCKINA great proportion of hypersensitive individuals manifest allergic reaction on their first exposure to peanut containing food, pointing to pre-existing sensitiza-tion. ...

Peanut allergy is one of the commonest food hypersensitivities causing fatal or near-fatal reactions. There is, currently, no preventive treatment and the incidence of severe allergic reactions during peanut desensitisation has limited its clinical use. Anti-immunoglobulin E therapy has been shown to be effective in preventing peanut-induced reactions but it does not result in long-term toleran...

The increasing cost of peanut production is a major concern in Iran. Therefore, developing the mechanization of peanut production is a necessity. In this regard, a three-phase Delphi study was conducted to identify the promoting and deterring factors affecting peanut cultivation mechanization in Guilan Province, the main peanut-producing region in Iran. After preliminary studies, 26 experts wer...

Emerging data suggest that measurement of serum IgE to peanut components can be clinically helpful and more accurate than IgE to whole peanut to predict peanut allergy. Not all studies have used prospective samples, multiple components and oral challenges. Currently, there are no data on this topic involving Italian children. 32 patients (23 males; median age 9 years) with reported history for ...

BACKGROUND Small studies suggest peanut oral immunotherapy (OIT) might be effective in the treatment of peanut allergy. We aimed to establish the efficacy of OIT for the desensitisation of children with allergy to peanuts. METHODS We did a randomised controlled crossover trial to compare the efficacy of active OIT (using characterised peanut flour; protein doses of 2-800 mg/day) with control ...