Negative ion photoelectron spectra of Ni, , Pd,, and Pt, are presented for electron binding energies up to 3.35 eV at an instrumental resolution of 8-10 meV. The metal cluster anions are prepared in a flowing afterglow ion source. Each dimer exhibits multiple low-lying electronic states and a vibrationally resolved ground state transition. Franck-Condon analyses yield the anion and neutral vibr...

Control over the integrative self-sorting of metallo-supramolecular assemblies opens up possibilities for introducing increased complexity and function into a single self-assembled architecture. Herein, the relationship between the geometry of three ligand components and morphology of three self-sorted heteroleptic [Pd2 L2 L'2 ]4+ cages is examined. Pd-mediated assembly of two bis-monodentate p...

Stress-induced increases in neonatal corticosterone demonstrate a unique shift from ACTH independence to ACTH dependence between postnatal day 2 (PD2) and day 8 (PD8) in newborn rats. This shift could be due to the binding of a bioactive, non--immunoreactive plasma ligand to the adrenocortical melanocortin 2 receptor (MC2R) (ACTH receptor). A potent MC2R antagonist would be useful to evaluate t...

Using isolated dog veins, we examined whether correlations exist between the regional differences in sensitivity to drugs and their embryogenesis. Twelve different veins were dissected. In the analysis, the data obtained previously for the inferior vena cava were also included. Spiral strips were prepared and the contractile responses to cumulative application of norepinephrine (NE), 5-hydroxyt...

Treatment of [PdCl2(PhCN)2] with diaryl telluride in 1 : 2 molar ratio gave mononuclear palladium complexes, trans-[PdCl2(TeR2)2] () (R = Mes () (Mes = 2,4,6-trimethylphenyl), Ph (), o-tol () (o-tol = ortho-tolyl)). Reaction of [PdCl2(TeMes2)2] with one equivalent of [PdCl2(PhCN)2] or Na2PdCl4 with TeRR' afforded chloro-bridged binuclear complexes, [Pd2(μ-Cl)2Cl2(TeRR')2] () (R/R' = Mes/Mes ();...

We report here that early exposure of guinea pig ventricular myocytes to hypertonic solution (approximately 400 mOsm compared to 280 mOsm in isotonic solution) increased the potency of rilmakalim to evoke ATP-sensitive K+ current 10 times (pD2 = 7.44 +/- 0.11 compared to pD2 = 6.49 +/- 0.18 in isotonic solution) without changing Emax, and observed effect was completely reversed by glibenclamide...

We studied seven healthy volunteers before and during acute (PD1) and chronic (PD2) ingestion of 30 g polydextrose (PD)/d. The energy value of PD was assessed after [U-14C]PD was added to the 10-g morning dose of PD during PD1 and at the end of PD2. Thirty-one +/- five percent (mean +/- SD) (PD1) and 29 +/- 4% (PD2) of the dose appeared in breath within 48 h. A small fraction of the ingested ra...

Complexation of 1,4-phenylenebis(methylene) diisonicotinate, L1, with cis-protected Pd(II) components, [Pd(L')(NO3 )2 ], in an equimolar ratio yielded binuclear complexes, 1 a-d of [Pd2 (L')2 (L1)2 ](NO3 )4 formulation where L' stands for ethylenediamine (en), tetramethylethylenediamine (tmeda), 2,2'-bipyridine (bpy), and phenanthroline (phen). The combination of 4,4'-bipyridine, L2, with the c...

Endothelin (ET) from a nontetrapod species has never been characterized, either structurally or biologically. A single molecular form of trout ET with 21-amino-acid residues was isolated in pure form from an extract of the kidney of the steelhead trout, Oncorhynchus mykissand its primary structure established as Cys-Ser-Cys-Ala-Thr-Phe-Leu-Asp-Lys-Glu10-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile20...