نتایج جستجو برای: p17 antigen

تعداد نتایج: 200845  

2016
Francesca Caccuri Maria Luisa Iaria Federica Campilongo Kristen Varney Alessandro Rossi Stefania Mitola Silvia Schiarea Antonella Bugatti Pietro Mazzuca Cinzia Giagulli Simona Fiorentini Wuyuan Lu Mario Salmona Arnaldo Caruso

The human immune deficiency virus type 1 (HIV-1) matrix protein p17 (p17), although devoid of a signal sequence, is released by infected cells and detected in blood and in different organs and tissues even in HIV-1-infected patients undergoing successful combined antiretroviral therapy (cART). Extracellularly, p17 deregulates the function of different cells involved in AIDS pathogenesis. The me...

Journal: :Blood 2012
Cinzia Giagulli Anna K Magiera Antonella Bugatti Francesca Caccuri Stefania Marsico Marco Rusnati William Vermi Simona Fiorentini Arnaldo Caruso

Exogenous HIV-1 matrix protein p17 was found to deregulate biologic activities of many different immune cells that are directly or indirectly involved in AIDS pathogenesis after binding to unknown cellular receptor(s). In particular, p17 was found to induce a functional program in monocytes related to activation and inflammation. In the present study, we demonstrate that CXCR1 is the receptor m...

2015
Wei-Ru Huang Hung-Chuan Chiu Tsai-Ling Liao Kuo-Pin Chuang Wing-Ling Shih Hung-Jen Liu Chunhong Yan

Avian reovirus (ARV) protein p17 has been shown to regulate cell cycle and autophagy by activation of p53/PTEN pathway; nevertheless, it is still unclear how p53 and PTEN are activated by p17. Here, we report for the first time that p17 functions as a nucleoporin Tpr suppressor that leads to p53 nuclear accumulation and consequently activates p53, p21, and PTEN. The nuclear localization signal ...

Journal: :Plastic and Reconstructive Surgery - Global Open 2017

2011
Cinzia Giagulli Stefania Marsico Anna K. Magiera Rosalinda Bruno Francesca Caccuri Ines Barone Simona Fiorentini Sebastiano Andò Arnaldo Caruso

The HIV-1 matrix protein p17 is a structural protein that can act in the extracellular environment to deregulate several functions of immune cells, through the interaction of its NH(2)-terminal region with a cellular surface receptor (p17R). The intracellular events triggered by p17/p17R interaction have been not completely characterized yet. In this study we analyze the signal transduction pat...

2012
Barbara Renga Daniela Francisci Claudio D'Amore Elisabetta Schiaroli Andrea Mencarelli Sabrina Cipriani Franco Baldelli Stefano Fiorucci

BACKGROUND Long-term remission of HIV-1 disease can be readily achieved by combinations of highly effective antiretroviral therapy (HAART). However, a residual persistent immune activation caused by circulating non infectious particles or viral proteins is observed under HAART and might contribute to an higher risk of non-AIDS pathologies and death in HIV infected persons. A sustained immune ac...

2014
Zhong Chuan-qing Cao Guang-xiang Huang Wei-yi Luan Xing-she Yang Yi-fei

Strain P17 was a bacterial strain identified as Bacillus megaterium isolated from ground accumulating phosphate rock powder. The fermentation broth of strain P17 and the yellow-brown soil from Nanjing Agricultural University garden were collected to conduct this study. The simulation of fixed insoluble phosphorous forms after applying calcium superphosphate into yellow-brown soil was performed ...

Journal: :The new microbiologica 2010
Song Li Luisa Bozzo Zhibin Wu Wuyuan Lu Fabio Romerio

The human immunodeficiency virus matrix protein p17 plays a critical role in many steps of the virus life cycle. In addition, p17 displays biological activities outside infected cells. Indeed, virus-neutralizing antibodies against p17 in plasma of infected patients correlate with slower disease progression, and p17 has been shown to interact with an as yet unidentified cell surface receptor exp...

2015
Barbara Renga Daniela Francisci Adriana Carino Silvia Marchianò Sabrina Cipriani Maria Chiara Monti Rachele Del Sordo Elisabetta Schiaroli Eleonora Distrutti Franco Baldelli Stefano Fiorucci

Liver disease is the second most common cause of mortality in HIV-infected persons. Exactly how HIV infection per se affects liver disease progression is unknown. Here we have investigated mRNA expression of 49 nuclear hormone receptors (NRs) and 35 transcriptional coregulators in HepG2 cells upon stimulation with the HIV matrix protein p17. This viral protein regulated mRNA expression of some ...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید