Our previous studies demonstrate that 17beta-estradiol limits chronic volume overload-induced hypertrophy and improves heart function in ovariectomized rats. One possible cardioprotective mechanism involves the interaction between estrogen, estrogen receptors, and proteins of the extracellular matrix (ECM). The impact of estrogen deficiency and replacement on left ventricular (LV) hypertrophy a...

Title: The combination therapy with alfacalcidol and risedronate improves the mechanical property in lumbar spine by affecting the material properties in an ovariectomized rat model of osteoporosis.

This study was conducted to enhance broccoli secondary metabolites; using plant biotechnology techniques and tissue culture as well evaluate the therapeutic effect of extract against osteoporosis in ovariectomized (OVX) rats. Cell technique implemented order achieve produce polyphenols from leaf explants broccoli. The high-performance liquid chromatography (HPLC) used polyphenolic profiles etha...

Osteoporosis is a systemic skeletal disease and there is a close relationship between the sympathetic nervous system (SNS) and bone metabolism. Leptin has been shown to regulate bone formation and bone resorption via the SNS. However, the effect of SNS on leptin signaling has not been clearly understood. In the present study, we studied the effect of propranolol on ovariectomy-induced osteoporo...

Role of the bed nucleus of stria terminalis (BST) in the control of gonadotropin release in the female rat was studied. Electrical stimulation of the BST on the day of diestrus II increased the serum concentration of FSH, but not of LH. The stimulation on the day of estrus increased serum concentration of LH as well as on the day of proestrus. In the ovariectomized and estrogen-treated rat, the...

Objective(s): Genistein, as a phytoestrogen found in legumes, has several biological activities in general and anti-diabetic activity particularly. In this study, we investigated the effect of genistein on proteins involved in β-cell proliferation, survival and apoptosis to further reveal its anti-diabetic potential in the ovariectomized diabetic rat. Materials and Methods: We used three-month-...

The present study was designed to investigate the role of estrogen receptor and KATP channel in cardioprotective effect remote aortic preconditioning rat heart. Remote is a phenomenon which brief episodes ischemia reperfusion organs protect target organ against sustained ischemia/ induced injury. Protective effects are well established heart, but their mechanisms still remain be elucidated. rat...

We report on the modulatory effects of chronic subcutaneous or oral estrogen and LY117018, a selective estrogen receptor modulator, on the release of nitric oxide in rings of rat aorta studied under isometric conditions. Dilator responses to acetylcholine (ACh; 10[8] to 10[-5] M) were obtained in phenylephrine (PE; 2 microM)-contracted aorta, and constrictor dose-response curves to PE (10[-8] t...

background: the fracture healing is impaired in osteoporosis. piper sarmentosum is a plant, which contains potent antioxidant, naringenin that may enhance fracture healing. the present histological study aimed to determine the effects of water extract of piper sarmentosum on the late phase of fracture healing in estrogen-deficient rats. methods: twenty four female sprague-dawley rats (200-250 g...

Introduction : Peptic ulcer occurs more frequently in men than in women, sex differences are less marked after 45 years of age probably because the incidence of ulcer increases in post menopausal women. The general assumption is that the ulcer differences between sexes are related in some way to sex hormones and that the female sex hormones protect against ulceration. The aim of the this study ...