Background Chronic orofacial pain conditions such as trigeminal neuropathic pain, reflex sympathetic dystrophy of the face, and temporomandibular pain disorders are debilitating pain conditions. They are known to respond poorly to treatment including opioids in human patients. There is a pressing need to better understand the mechanisms of these chronic orofacial pain conditions so that new and...

Orofacial granulomatosis (OFG) is a granulomatous disease of the orofacial region which appears usually as a persistent and/or recurrent labial soft tissue swelling in the orofacial region and is characterized histologically by a granulomatous inflammation. OFG may cause significant cosmetic and functional problems but can be prevented if the disease is diagnosed early and promptly treated. Thi...

The year 2013-2014 has been designated the Global Year Against Orofacial Pain by the International Association for the Study of Pain. Accordingly, a multidisciplinary Canadian and international group of clinical, research and knowledge-transfer experts attended a workshop in Montreal, Quebec. The workshop had two aims: to identify new pathways for innovative diagnosis and management of chronic ...

Pain in the oral and craniofacial system represents a major medical and social problem. Indeed, a U.S. Surgeon General’s report on orofacial health concludes that, ‘‘. . .oral health means much more than healthy teeth. It means being free of chronic oral-facial pain conditions. . .’’ [172]. Community-based surveys indicate that many subjects commonly report pain in the orofacial region, with es...

BACKGROUND Currently, orofacial sequelae are recognized as very influential on the quality-of-life for a victim of orofacial damage. Therefore, correct forensic assessment for indenisation purposes is mandatory. However, orofacial damage is frequently reduced to organic components, which results in a forensic assessment process, which are inadequate. This study aims to improve the orofacial dam...

Introduction: Long-term levodopa treatment of Parkinson’s disease (PD) is frequently complicated by spontaneously occurring involuntary muscle movements called dyskinesia. The exact pathological mechanism of this complication has not yet been elucidated. We have previously demonstrated that in PD patients the vulnerability to develop peripheral but not orofacial dyskinesia is associated w...

Critically ill patients admitted into the intensive care units are susceptible to a wide array of complications that can be life-threatening, or lead long-term complications. Some inherent patient’s condition and others related therapeutics procedure. The prolonged prone positioning mechanical ventilation devices first risk factors for orofacial We report case 47-year-old male patient, with his...

background and aims. orofacial pain is one of the most common reasons for attendance at the dental clinic. the prevalence and the sources of orofacial pain vary from place to place and patients’ response to pain also differs. the aim of this study was to determine the prevalence and pattern of orofacial pain as well as the factors influencing patients’ response to orofacial pain among patients ...

Because temporomandibular disorders (TMDs) rehabilitation continues to be a challenge, a more comprehensive picture of the orofacial functions in patients with chronic pain is required. This study assessed the orofacial functions, including surface electromyography (EMG) of dynamic rhythmic activities, in patients with moderate-severe signs and symptoms of chronic TMD. It was hypothesized that ...

      Murraya koenigii L. (Rutaceae), commonly known as curry leaf tree, closely associated with south India where the word “curry” originates from the Tamil “kari” for spiced sauces. Curry leaves are a rich source of carbazole alkaloids which possess various biological activities such as antitumor, antioxidant and anti-inflammatory. Curry leaf has a potential role in the treatment of diabetes....