Areca nut, commonly called as betel nut or supari, is a fruit of areca catechu palm tree, which is native of South Asia and Pacific Islands. The seed or endosperm is consumed fresh, boiled or after sun drying or curing. Chewing areca nut is thought to have central nervous system stimulating effect and along with this it is known to have salivary stimulating and digestive properties. According t...

Oral submucous fibrosis is a chronic insidious disease and a well-recognized potentially malignant condition of the oral cavity. It is a collagen related disorder associated with betel quid chewing and characterized by progressive hyalinization of the lamina propria. Objectives: It is traditionally held that in oral submucous fibrosis the hyalinization process starts from the lamina propria and...

Oral submucous fibrosis (OSMF) is characterized by excessive deposition of collagen in the connective tissue leading to secondary changes in epithelium. It has multifactorial etiology. This case reports Oral Submucous Fibrosis occurring in a 28 year old male with a history of betel quid chewing. Various treatment modalities are proposed such as nutritional support, immunomodulatory drugs, physi...

background and aims. many oral squamous cell carcinomas develop from potentially malignant disorders (pmds) which include a variety of lesions and conditions characterized by an increased risk for malignant transformation. this study evaluated the quantitative expression of egfr in normal oral mucosa, oral leukoplakia and oral submucous fibrosis to predict the malignant risk in compliance with ...

An evaluation of the malignant potential of submucous fibrosis, based on observations of 89 patients with the disease in Ernakulam District, Kerala, India was done. Out of the 89 patients, 12 were referred patients and 77 were diagnosed in population based studies. At the time of first examination oral cancer was found to be coexistent in nine (10%) cases. For 66 patients follow-up observations...

Oral submucous fibrosis is a chronic, progressive, disabling and scarring disease that affects the entire oral cavity, sometimes the pharynx, and rarely the larynx which predominantly affects the people of southeast Asia. It is characterized by blanching and stiffness of the oral mucosa, which causes progressive limitation of mouth opening and intolerance/ burning sensation to hot and spicy foo...

Aim: Altered lipid profile patterns have been associated with pre-malignancies and malignancies because lipids play a vital role in the maintenance of cell integrity. The present study evaluated alterations in serum lipid profile in untreated patients with oral submucous fibrosis (OSF) and compared the changes in serum lipid profiles among various histological grades of OSF. Materials and metho...

Oral submucous fibrosis (OSMF), which presents with a severe degree of trismus, is a great surgical challenge. The surgical procedures include excision of fibrous bands with or without coverage of the surgically created defect. The use of vascularised flaps such as the palatal pedicled flap, tongue flaps, use of buccal fat pad and nasolabial flaps are becoming increasingly popular. We present a...

The IARC monographs recently classified chewing betel quid without tobacco as a human carcinogen. Several studies in Taiwan have reported that betel quid without tobacco may increase the risk of oral precancers such as oral leukoplakia and oral submucous fibrosis. However in India, since most betel quid chewers prefer to add tobacco to the quid, the independent effect of betel quid on the risk ...

Introduction: Expression of p53 gene is one of the common findings in premalignancies and malignancies of the oral cavity. The aim of the study was to know whether P53 protein is overexpressed in histological sections of oral submucous fibrosis, oral leukoplakia and oral squamous cell carcinoma. The aim of the present study was to determine the overexpression of P53 protein in histological sect...