OBJECTIVE AND DESIGN Gliclazide has been associated with a low risk of hypoglycemic episodes and beneficial long-term cardiovascular safety in observational cohorts. The aim of this study was to assess in a systematic review and meta-analysis of randomized controlled trials the safety and efficacy of gliclazide compared to other oral glucose-lowering agents (PROSPERO2013:CRD42013004156). DATA...

Diabetes mellitus is a condition of increased blood glucose level in the body. Antihyperlipidemic drugs like statins and fibrates are widely used for prophylactic treatment in dyslipideamia and atherosclerosis. Diabetic dislipidemia exists with increased triglycerides, low HDL and high LDL levels. Hence, with oral hypoglycemic drugs, the addition of a lipid-lowering drug is necessary for contro...

AIMS To describe the characteristics and associated risk factors of patients with established diabetes who required Emergency Department (ED) care for severe hypoglycemia. METHODS We performed an observational retrospective study to identify all cases of severe hypoglycemia among attendees at the EDs of three Italian University hospitals from January 2010 to December 2014. RESULTS Overall, ...

OBJECTIVE To evaluate whether use of oral hypoglycemic agents is associated with an altered breast cancer risk in women. RESEARCH DESIGN AND METHODS Using the U.K.-based General Practice Research Database, we conducted a nested case-control analysis among 22,621 female users of oral antidiabetes drugs with type 2 diabetes. We evaluated whether they had an altered risk of breast cancer in rela...

Numerous oral antidiabetic drugs with different mechanisms of action have been developed to lower glucose and delay the occurrence of serious complications in patients with type 2diabetes [1]. For glycemic control in diabetic patients, monotherapy with an oral antidiabetic agent is not adequate to achieve satisfactory blood glucose control [2]. Thus, combination regimens which include drugs wit...

The purpose of the current review is to bring up date some studies and data about effects hypoglycemic oral drugs in combination with DPP-4 inhibitors. As medicine pharmaceutical industry are revolutionary type 2 diabetes protocols, scientists made a close research on patients that have combined metformin plus sulfonyurea Statistics showed sulfonylurea compared inhibitors, metformin, increased ...

77irty six patients with non insulin dependent diabetes mellitus, whose blood sugar was not controlled with maximal doses of oral hypoglycemic agents and did not accept insulin treatment, were selected for this study. the patients were randomly divided into two groups, the treatment group and the control group. the treatment group received oral hypoglycemic agent and chloroquine (150 mg twice d...

Objective: To determine the effectiveness of therapy with basal insulin analogs administered in poorly controlled type 2 diabetes mellitus patients switching from oral antidiabetic drugs with or without NPH insulin. Patients and methods: Observational retrospective study carried out in 250 type 2 diabetes mellitus patients who switched from oral antidiabetic drugs with or without insulin NPH to...

Diabetes mellitus is one of the world’s major diseases. It currently affects an estimated143 million people worldwide and the number is growing rapidly. In the India, about 1-5% population suffer from diabetes or related complication. So there is need to cure this disease. Anti-diabetic drugs treat diabetes mellitus by lowering glucose levels in the blood. With the exceptions of insulin, exenat...

BACKGROUND The incidence of acute liver failure or serious liver injury in diabetic patients is needed to evaluate the safety of hypoglycemic drug therapy. METHODS We conducted a retrospective cohort study of 5 health maintenance organizations. Study patients were 171,264 health plan members 19 years or older when they received oral hypoglycemic drugs or insulin between April 1, 1997, and Jun...