A double-blind, randomized, vehicle-controlled, parallel-group trial was performed to compare the efficacy and tolerability of tazarotene 0.1% gel and vehicle gel in 31 patients with fingernail psoriasis. Patients were randomized to receive tazarotene or vehicle gel, which they applied each evening for up to 24 weeks to 2 target fingernails, one under occlusion and one unoccluded. The tazaroten...

A previously healthy man, 43 years of age, was referred to the dermatology department with a one-year history of fingernail onychomycosis. His condition was refractory to oral antifungal treatment (terbinafine 250 mg QD for three months). On physical examination, nail pitting and onycholysis affecting seven fingernails was noted (Figure 1A). He also had mild erythematous silvery-white scaly pat...

A 38-year-old man, without previous history of disease, was diagnosed with stage IIIB high-grade T-cell non-Hodgkin's lymphoma. He initially received eight cycles of cyclophosphamide (1350 mg), doxorubicin (90 mg), vincristine (2 mg) and prednisone (100 mg/day for 5 days) ^ CHOP regimen ^ with good response. The patient was disease-free for 3 years, after which the disease relapsed and he was s...