نتایج جستجو برای: one locus mismatch
تعداد نتایج: 2075455 فیلتر نتایج به سال:
Hereditary nonpolyposiscoborectalcarcinoma is a major cancer ma ceptibifity syndrome known to be caused by inheritance of mutations in at least four genes such as hMSH2, hMLHJ, hPMSI, and !SPMS2which encode components of a DNA mismatch repair system. The hMLHJ genomic locus on chromosome 3p has been cloned and shown to cover @58 kilobases ofgenomic DNA and contain 19 exons. The sequence ofall o...
Single-nucleotide polymorphisms (SNPs) represent the most prevalent class of genetic markers available for linkage disequilibrium or cladistic analyses. PCR primers may be labeled with fluorescent dyes and used to rapidly and accurately differentiate among alleles that are defined by a single-nucleotide differences. Here, we describe the primer-mediated detection of SNPs based on primer mismatc...
We examined current outcomes of unrelated donor allogeneic hematopoietic cell transplantation (HCT) to determine the clinical implications of donor-recipient HLA matching. Adult and pediatric patients who had first undergone myeloablative-unrelated bone marrow or peripheral blood HCT for acute myelogenous leukemia, acute lymphoblastic leukemia, chronic myelogenous leukemia, and myelodysplastic ...
Fifteen variants with >/=30-fold resistance to N-methyl-N-nitrosourea were isolated from the Burkitt's lymphoma Raji cell line. Eight had received a single treatment with a highly cytotoxic dose. The remainder, including the previously described RajiF12 cell line, arose following multiple exposures to initially moderate but escalating doses. Surprisingly, methylation resistance arose in three c...
Recent work has investigated children’s developing understanding of the anatomical locus of identity. In two studies, we extend this work by exploring the role of the mind as opposed to the brain in children’s conceptualization of identity. In Experiment 1, an analysis of natural language indicated that adults use the term mind more frequently than the term brain with reference to identity-rela...
Background: Health locus of control is an important variable in diabetes. The aims of the present study were to investigate the role of health locus of control in predicting psychosocial adjustment to illness and compare psychosocial adjustment to illness and dimensions of health locus of control among male and female type 2 diabetic patients. Methods: One hundred and eighteen patients were ...
Frequent loss of Fhit expression has been reported in human gastrointestinal tract carcinomas; opinions remain divergent regarding Fhit expression in colorectal carcinoma (CRC) cases. Recent studies have suggested that Fhit inactivation can be a consequence of defects in mismatch repair proteins, particularly Msh2. Immunohistochemical analysis of Msh2 and Fhit protein expression in 62 CRC cases...
purpose: the aim of this study was to investigate the relations of locus of control, rumination, and worry with depression and anxiety in a sample of depressed and anxious patients. a second purpose of the study was to examine the mediating role of rumination and worry on the relationship between locus of control with depression and anxiety. method: one hundred and twelve patients with major de...
the increased risk of hemolytic reactions and erythrocyte recovery delay in abo incompatible hematopoietic stem cell transplantation (hsct) is well established. effects of abo incompatibility on transplantation outcomes is evaluated in this study. we prospectively followed 501 patients undergoing allogeneic stem cell transplantation according to abo compatibility groups of minor, major and bidi...
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