Loss of cognition is one of the age related mental problems and a characteristic symptom of neurodegenerative disorders like Alzheimer's. Crataeva nurvala Buch-Ham, a well explored traditional Indian medicinal plant of Westernghats, is routinely used as folkloric medicine to treat various ailments in particular urolithiasis and neurological disorders associated with cognitive dysfunction. The o...

BACKGROUND The aerial parts of Vitis vinifera (common grape or European grape) have been widely used in Ayurveda to treat a variety of common and stress related disorders. In the present investigation, the seed extract of V. vinifera was evaluated for antistress activity in normal and stress induced rats. Furthermore, the extract was studied for nootropic activity in rats and in-vitro antioxida...

Gold, P. E. (1986) Behav. Neural Biol. 46,87-98 Jensen, L. H., Petersen, E. N., Braestrup, C., Honore, T., Kehr, W., Stephens, D. N., Seidelmann, D. & Schmiechen, R. (1984) I-’sycliopharmricologyo~ 83,2492 5 6 Jensen, L. H., Stephens, D. N., Sarter, M. & Petersen, E. N. ( 1 987) Bruin. Res. Bull. 19, 359-364 Petkow, V., Georgier, V., Getova, D. & Petkov, V. (1983) Acfu I’hysiol. I’harmacol. Bul...

The structure of the title compound, C(14)H(28)N(3)O(2) (+)·HSO(4) (-), a nootropic drug (pramiracetam) investigated for cognition-enhancing properties, is closely similar to that of the previously determined acetonitrile solvate, both structures being characterized by the presence of ribbons of hydrogen-bonded ions. The pyrrolidine ring adopts an envelope conformation.

The present study was carried out to evaluate CNS activity of ethanolic extract of roots of Anacyclus pyrethrum that includes general behavior studies, sedative, muscle relaxant, anxiolytic, nootropic activity and antidepressant studies in rats. The results reveal potential neuropharmacological activity of Anacyclus pyrethrum as nootropic and also having antidepressant property. Further neuroch...

It is widely believed that nootropic (cognition-enhancing) agents produce their therapeutic effects by augmenting excitatory synaptic transmission in cortical circuits, primarily through positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate receptors (AMPARs). However, GABA-mediated inhibition is also critical for cognition, and enhanced GABA function may be likewise ther...