Objective: The present study was undertaken to evaluate the antidepressant and nootropic potential of aqueous extract of Indigofera tinctoria (ITAE). Methods: Antidepressant activity of ITAE was evaluated in mice by using the forced swim test (FST), tail suspension test tail suspension test and tetrabenazine induced catalepsy and ptosis models at doses of 250 and 500 mg/kg orally. Nootropic act...

Spinal trau ma occurs when there is damage to the spinal cord that results in a bruise, a partial tear, or a complete tear. Because the spinal cord is the central carrier of signals throughout the body, damage to the spinal cord can have serious consequences. During a 5 year period (2005 – 2009), 39 patient’s spinal trauma – were treated in the Neurology department of RCSUMA. The patients were ...

Nootropic effect of alcoholic (ALE; 50, 75, 100 mg/kg) and aqueous (AQE; 100, 200, 400 mg/kg) extracts of P. tuberosa was evaluated by using Elevated Plus Maze (EPM), scopolamine-induced amnesia (SIA), diazepam-induced amnesia (DIA), clonidine-induced (NA-mediated) hypothermia (CIH), lithium-induced (5-HT mediated) head twitches (LIH) and haloperidol-induced (DA- mediated) catalepsy (HIC) model...

The aerial parts of Vitis vinifera Linn. (Common grape, Hindi ⎯ Angur) have been widely used in Ayurveda to treat a variety of common and stress related disorders. The seed extract of grapes was evaluated by Sreemantula and others for antistress activity in normal and stress induced rats. Furthermore, the extract was studied for nootropic activity in rats and in vitro antioxidant potential to c...

Nootropics or smart drugs are well-known compounds or supplements that enhance the cognitive performance. They work by increasing the mental function such as memory, creativity, motivation, and attention. Recent researches were focused on establishing a new potential nootropic derived from synthetic and natural products. The influence of nootropic in the brain has been studied widely. The nootr...

Bacopa monnieri is a plant used as a nootropic in Ayurveda, a 5000-year-old system of traditional Indian medicine. Although both animal and clinical studies supported its role as a memory enhancer, the molecular and cellular mechanism underlying Bacopa's nootropic action are not understood. In this study, we used deep sequencing (RNA-Seq) to identify the transcriptome changes upon Bacopa treatm...

The effect of different nootropic drugs (piracetam, pyritinol, meclofenoxate, methylglucamine orotate, dihydroergotoxine, nicergoline, vinpocetine) on the duration of immobility in the behavioural despair test in mice was studied. All tested nootropics exhibited a dose-related reduction in immobility. In connection with the discussed role of monoaminergic processes in the state of immobility ou...

Oxidative stress is intensely linked with neurodegenerative disorders, especially Alzheimer’s disease (AD). Searching for medicinal plant with the nootropic activity for controling the development and progression of AD has received extensive consideration. The plant Phyllanthus reticulatus (PR) Poir. is known in Bengali as Panjuli belongs to family Euphorbiaceae. Previous studies have shown the...

The objective of the present study is to investigate the nootropic activity of aqueous and 95% ethanolic extracts of aerial parts of Alternanthera sessilis Linn. R.Br.ex.DC (Amaranthaceae). Alternanthera sessilis Linn, commonly known as sessile joy weed a well known herb with fleshy leaves. The herb is mainly used as cholagogue, galactogue, intellect promoting, strength, diarrhea, constipation,...

Boerhaavia diffusa roots (Punarnava mool) are in use since beginning of Ayurvd era for various therapeutic benefits. This Research Paper basily enquires into work done in the field of its Rejuvenation (Rasayan) benefits. The name Punarnava itself means ‘Rejuvenation’. In the modern allopathic terms, it has been translated as adaptogenic, immumodulatory, anti-oxidant aphrodisiac and nootropic ac...