RATIONALE The cannabinoid system consists of a complex array of receptors, substances with agonist/antagonist properties for those receptors, biosynthetic machineries and mechanisms for cellular uptake and degradation for endocannabinoids. This system is in interrelation with other systems that comprise lipid mediators like prostaglandins/leukotrienes systems. A clear antagonist, additive or sy...

Nonsteroidal anti-inflammatory drugs (NSAIDs) are a diverse class of drugs commonly used for the treatment of inflammatory conditions, have been found to be highly effective in preventing and treating many types of cancers. However, toxicity from cyclooxygenase (COX) inhibition and the suppression of physiologically important prostaglandins limits their use for cancer chemoprevention and prompt...

Nonsteroidal anti-inflammatory drugs (NSAIDs) are the drugs most frequently involved in hypersensitivity reactions. These reactions include various clinical entities with different mechanisms leading to the release of inflammatory mediators. Characterization of patients based on clinical manifestations and suspected underlying mechanisms is critical for implementation of adequate diagnostic pro...

Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most commonly used drugs worldwide. NSAIDs are used for a variety of conditions including pain, rheumatoid arthritis, and musculoskeletal disorders. The beneficial effects of NSAIDs in reducing or relieving pain are well established, and other benefits such as reducing inflammation and anticancer effects are also documented. The undesirable ...

Peptic ulcer disease (PUD) is predicted to affect between 0.1 and 0.3 percent of the population each year. PUD develops at a rate roughly 1% per year in Helicobacter pylori (H. pylori) infected persons, which 6 10 times higher than uninfected people. The prevalence increases with age both duodenal stomach ulcers. Two factors contribute peptic disease: H. infection use nonsteroidal anti-inflamma...

A biosensor for rapid determination of nonsteroidal anti-inflammatory drugs (NSAIDs) is described based on the inhibition of cyclooxygenase enzyme (both isoforms) by NSAIDs. The results show the full validity of the method, which has also been optimized by comparing the inhibition of two enzyme isoforms, COX-1 and COX-2, in the presence of different tested pharmaceutical drugs (diclofenac, napr...

Aspirin and nonaspirin nonsteroidal antiinflammatory drugs (NSAIDs) inhibit platelet cyclooxygenase, thereby blocking the formation of thromboxane A2. These drugs produce a systemic bleeding tendency by impairing thromboxane-dependent platelet aggregation and consequently prolonging the bleeding time. Aspirin exerts these effects by irreversibly blocking cyclooxygenase and, therefore, its actio...

Background: Curcumin, a major constituent of tumeric powder, is renowned for its anti-inflammatory effect but the studies of its effects on nonsteroidal anti-inflammatory drugs (NSAIDs)-induced gastropathy are still

Acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs) and opioids are available as analgesics in dentistry. They each have specific advantages, disadvantages, indications and contraindications. This article provides a brief review of their role in the management of acute postoperative pain.