ally 4 different kinds of lupus, of which SLE is the most common form. In addition to SLE, there is discoid lupus erythematosus, drug-induced lupus erythematosus, and neonatal lupus. Discoid, or cutaneous, lupus is limited to the skin, where it manifests as a variety of different rashes.1 Drug-induced lupus, which appears similar to SLE, usually dissipates within several weeks of discontinuatio...

Background: Neonatal lupus erythematosus is an uncommon disease. Congenital complete heart block (CCHB) usually happens in neonates with maternal systemic lupus erythematosus. The most prevalent presentation of CCHBis bradycardiathatcanbediagnosed through an electrocardiogram. Case report: Here in, we present the case of a full-term male neonate with gestational age of 37 weeks and birth weigh...

Definiton Lupus erythematosus (LE) is an autoimmune disorder, in which the body's own immune system attacks its own tissues, especially components of the cellular nuclei. Lupus is the latin for wolf and erythematosus indicates red-like. Thus, LE stands for ”the red wolf” which should be in contrast to lupus vulgaris, ”the common wolf” which in the old days designated the skin of the face in pat...

BACKGROUND Congenital grouped skin lesions are alarming signs of a variety of threatening diagnoses of quite different origin. The present case report shows an impressive clinical pattern of a neonate and illustrates the difficulty in differential diagnosis of mixed connective tissue disease and neonatal lupus erythematosus in newborns. This reported case is to our knowledge the first descripti...

background: systemic lupus erythematosus is a systemic autoimmune disorder with unclear etiology. the importance of some genes in the development of systemic lupus erythematosus has been implicated. the gene polymorphism in codon 72 has attracted a lot of attention and its role in the occurrence or progression of many cancers and autoimmune diseases especially systemic lupus erythematosus has b...

Neonatal lupus erythematosus is an autoimmune disease resulting from the trans-placental passage of maternal anti-SSA/Ro, anti-SSB/La, and less frequently anti-RNP antibodies to the foetus. At the time of diagnosis 50% of mothers are asymptomatic. Neonatal manifestations of this multisystem disease may include congenital heart block, cutaneous lesions and haematological abnormalities. We presen...

at present, some clinical presentations and serological parameters such as products of complement activation and elevation of autoantibodies (e.g. dsdna antibodies), erythrocyte sedimentation rate (esr), levels of c-reactive protein (crp), or cytokines such as il-2/il-2 receptor, il-6 and il-10 are used as indirect serological markers with variable degrees of significance. to date, no specific ...

the central immunological disturbance in systemic lupus erythematosus (sle) is autoantibody production. some of these antibodies affecting components of the cell nucleus are the major characteristics of sle. the present study was aimed to assess importance of anticardiolipin (acl) antibody and its association with clinical state in sle patients. a cross sectional study was performed on 100 pati...