BACKGROUND 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), a commercial chemotherapeutic drug for treating malignant brain tumors, has poor thermal stability and a short half-life. Immobilization of BCNU on a nanocarrier might increase the thermal stability of BCNU and extend its half-life. METHODS Nanosized graphene oxide (GO) could be modified by polyacrylic acid (PAA) to improve the aqueous s...

A novel therapeutic scaffolding system of engineered nanocarriers within a foam matrix for the long-term and sequential delivery of growth factors is reported. Mesoporous silica nanospheres were first functionalized to have an enlarged mesopore size (12.2nm) and aminated surface, which was then shelled by a biopolymer, poly(lactic acid) (PLA) or poly(ethylene glycol) (PEG), via electrospraying....

Developing efficient methods for targeting cancer cells and encapsulating drugs coupled with activated release holds enormous potential for cancer cell imaging and therapy. Herein, a novel dual-targeted nanocarrier was developed on the basis of gold nanoparticles modified with a dense shell of synthetic oligonucleotides. The folic acid functionalized single-stranded DNA was designed to target t...

A novel "smart" multifunctional drug delivery system was successfully developed to respond to the up-regulated matrix metalloprotease 2 (MMP2) in the tumor microenvironment and improve cancer cell-specific delivery of loaded drugs. The system represents a surface-functionalized liposomal nanocarrier, for which two functional polyethylene glycol (PEG)-lipid conjugates were synthesized and charac...

With the high rate of mortality associated with breast cancer among women, treatment has attracted great deal attention globally. To reduce exposure body organs to cytotoxicity common chemotherapeutic drugs, local co-delivery selected chemotherapeutics emerged as a solution. In this work, an electrospun composite including co-drug-loaded graphene oxide-based nanocarrier is fabricated for antica...

Objective(s): The purpose of this study was preparation and evaluation of PVA-Fe3O4 nanofibers as nanocarrier of doxorubicin (DOX) by measuring their drug release together with their in vitro cytotoxicity toward cancer cells at different pH values. Methods: Fe3O4 nanoparticles were synthesized by coprecipitation...

Nanocarriers can aid therapeutic agent administration to the lung, but controlling drug delivery from these systems after deposition in the airways can be problematic. The aim of this study was to evaluate if chemically mediated shell permeabilisation could help manipulate the rate and extent of nanocarrier drug release. Rifampicin was loaded into lipid shell (loading efficiency 41.0±11.4%, siz...

The development of nanocarriers that selectively release guest molecules on sensing a particular biological signal is being actively pursued in nanomedicine for diagnostic and therapeutic purposes. Here we report a protein-based nanocarrier that opens in the presence of intracellular adenosine-5'-triphosphate (ATP). The nanocarrier consists of multiple barrel-shaped chaperonin units assembled t...

objective: in order to overcome the limitation of systemic administration of methylene blue, this study investigated the encapsulation of methylene blue in polymeric liposomes and drug release following sonication. methods: we encapsulated methylene blue into nanoliposomes. the dynamic light scattering (dls) method was used to measure the size distribution of the liposomes. after loading methyl...

Ocular drug delivery is challenging due to the presence of anatomical and physiological barriers. These barriers can affect drug entry into the eye following multiple routes of administration (e.g., topical, systemic, and injectable). Topical administration in the form of eye drops is preferred for treating anterior segment diseases, as it is convenient and provides local delivery of drugs. Maj...