BACKGROUND Mitral valve prolapse (MVP) is common in women. Other clinical features such as flexibility and hyperlaxity are often associated with MVP, as there is a common biochemical and histological basis for collagen tissue characteristics, range of joint motion, and mitral leaflet excursion. OBJECTIVE To confirm whether adult women with MVP are more flexible and hypermobile than those with...

Vaults are ribonucleoprotein particles with a distinct structure and a high degree of conservation between species. Although no function has been assigned to the complex yet, there is some evidence for a role of vaults in multidrug resistance. To confirm a direct relation between vaults and multidrug resistance, and to investigate other possible functions of vaults, we have generated a major va...

Oxygen molecule modulates tumour response to radiotherapy. Higher radiation doses are required under hypoxic conditions to induce cell death. Hypoxia may inhibit the non-homologous end-joining DNA repair through down regulating Ku70/80 expression. Hypoxia induces drug resistance in clinical tumours, although the mechanism is not clearly elucidated. Vaults are ribonucleoprotein particles with a ...

Major vault protein (MVP) is identical to lung resistance-related protein (LRP), which is the major component of vaults. Vaults are considered to play a protective role against xenobiotics and other types of stress. In a previous study, we reported that the expression levels of MVP in SW620 human colon cancer cells were increased in hypertonic culture medium with sucrose. However, the molecular...

Despite their ubiquitous expression and high conservation during evolution, precise cellular functions of vault ribonucleoparticles, mainly built of multiple major vault protein (MVP) copies, are still enigmatic. With regard to cancer, vaults were shown to be upregulated during drug resistance development as well as malignant transformation and progression. Such in a previous study we demonstra...

Vaults are ribonucleoprotein particles with a distinct structure and a high degree of conservation between species. Although no function has been assigned to the complex yet, there is some evidence for a role of vaults in multidrug resistance. To confirm a direct relation between vaults and multidrug resistance, and to investigate other possible functions of vaults, we have generated a major va...

Postural orthostatic tachycardia syndrome and neurocardiogenic syncope are clinical manifestations of autonomic nervous system dysfunction (dysautonomia) that can lead to impaired daily functions. We report two young patients presenting with dysautonomia and autoimmune disease who both received autologous adipose stem cells (ASCs) infusions. This report is the first description of ASCs therapy ...

Mitral valve prolapse (MVP) is defined as posterior displacement of all or part of MV leaflet(s) beyond MV annulus at least 2 mm into the left atrium (LA) during systole, with or without mitral leaflet thickening, but prolapsed leaflet(s) pointing towards apex in systole [1]. Mitral regurgitation (MR) is a common complication of MVP. Moreover, MVP with flail leaflet(s) is a severe form of MVP w...

purpose: to investigate the association between acute corneal hydrops in patients with keratoconus (kcn) and mitral valve prolapse (mvp). methods: this case-control study included kcn patients with corneal hydrops who were referred to labbafinejad medical center or a collaborating private clinic from march 2006 to march 2008 as the case group. the control group included age- and sex-matched ind...

To the Editor: Delling et al wrote an interesting article on the familial clustering of mitral valve prolapse (MVP), using a well-characterized population cohort with 3-generation data. This article paves the way to further studies on the genetic determinants of MVP, but also on its clinical significance once survival data will be analyzed. As the authors acknowledge, this work is partly retros...