CONTEXT The aim of this article was to review the clinical presentation, pathogenesis, and management of thyrotoxic periodic paralysis (TPP). EVIDENCE ACQUISITION A MEDLINE search was conducted for articles published during the last 40 yr based on the key words thyrotoxic periodic paralysis and hypokalemic periodic paralysis. A total of 281 primary articles and 168 references of the retrieved...

Hereditary muscle channelopathies are caused by dominant mutations in the genes encoding for subunits of muscle voltage-gated ion channels. Point mutations on the human skeletal muscle Na+ channel (Nav1.4) give rise to hyperkalemic periodic paralysis, potassium aggravated myotonia, paramyotonia congenita and hypokalemic periodic paralysis type 2. Point mutations on the human skeletal muscle Ca2...

Thyrotoxic periodic paralysis is a disease characterized by recurrent episodes of paralysis and hypokalemia during a thyrotoxic state. Thyrotoxic periodic paralysis is a common complication of hyperthyroidism in Asian populations, but can affect other ethnic groups as well. Due to population mobility, Thyrotoxic periodic paralysis is increasingly common in Western countries. Early diagnosis and...

objective the guillain-barre syndrome (gbs) is characterized by the acute onset of rapidlyprogressive, symmetric muscle  weakness with absent or decreased deep tendon reflexes. gbs is the most common cause of acute flaccid paralysis in childhood, with an incidence of 0.6-4 per 100 000 population per year. the clinical features are distinct and obtaining patient's history and conducting an exami...

Paralysis of the upper extremity severely restricts independence and quality life after spinal cord injury. Regaining control hand arm movements is highest treatment priority for people with paralysis, 6-fold higher than restoring walking ability. Nevertheless, current approaches to improve function typically do not restore independence. Spinal stimulation an emerging neuromodulation strategy m...

Chronic paralysis of rat embryos during the last 4 to 6 prenatal days causes a diminution in skeletal muscle fiber numbers but inhibits motoneuron death. Consequently, as paralyzed muscles develop, an increased number of motoneurons attempts to form synapses at a reduced number of synaptic sites. Paralyzed muscle fibers receive their synapses at a single endplate, as in control muscles, but the...

Thyrotoxic hypokalemic periodic paralysis (THPP) is a rare complication of hyperthyroidism and an uncommon form of hypokalemic periodic paralysis. Its differentiation of more common forms of periodic paralysis is important because aggressive treatment can place the patient at risk for rebound hyperkalemia. Treatment of the underlying thyroid dysfunction cures the muscle symptoms. Here we descri...

The diaphragm has a major role in inspiration. The muscle separates the mostly negative pressure chest cavity, from the positive pressure abdomen. The displacement of the muscle with inspiration expands the chest, augmenting the negative pleural pressure, thereby forcing air flow into the lung. However paralysis of the muscle, unilaterally or even bilaterally, is compatible with life in most ca...