The reversible potassium channel blocker 4-aminopyridine is effective in the treatment of numerous cerebellar dysfunctions, such as episodic ataxia type 2 and downbeat nystagmus syndrome. In 2011, its sustained release form, dalfampridine, was admitted in Europe for the treatment of walking difficulties in patients with multiple sclerosis (MS). Here we report the case of a 44-year old patient w...

Background and aims: Multiple sclerosis (MS) is one of the most common progressive neurological diseases in young people. Tremor a debilitating symptom people with MS, significantly affecting their quality life. This study aimed to evaluate effect self-care program based on mobile application tremors MS. Methods: semi-experimental was conducted 72 patients MS Chaharmahal Bakhtiari province 2019...

1. An animal model for the study of cerebellar intention tremor was produced by implanting cryoprobe sheaths alongside the dentate and interpositus nuclei of the cerebellum in three Cc>bris monkeys. These monkeys were trained to make fast flexion and extension elbow movements by moving a handle in a horizontal arc and to resist perturbations applied to the handle as it was held within target re...

Using coherence analysis (which is an extensively used method to study the correlations in frequency domain, between two simultaneously measured signals) we estimate the time delay between two signals. This method is suitable for time delay estimation of narrow band coherence signals for which the conventional methods cannot be reliably applied. We show by analysing coupled Rössler attractors w...

The complex dynamics of the human hand/arm system need to be precisely controlled to produce fine movements such as those found in handwriting. This study employs dynamical systems analysis techniques to further understand how this system is controlled when it is functioning well and when it is compromised through motor function degradation (e.g. from tremor). Seven people with and 16 people wi...

Thalamomuscular coherence in essential tremor (ET) has consistently been detected in numerous neurophysiological studies. Thereby, spatial properties of coherence indicate a differentiated, somatotopic organization; so far, however, little attention has been paid to temporal aspects of this interdependency. Further insight into the relationship between tremor onset and the onset of coherence co...

For many diseases various methods for the diagnosis and treatment monitoring are available. Presently, such methods are not established for an investigation of tremor diseases, although the different forms of tremor are common neurological symptoms and occur frequently in various neurological diseases and also other conditions. We developed an easy-to-use application for tremor-analysis and rec...

This paper reports on work carried out to date, and future directions for, a project that intends to measure and control tremor in individuals with multiple sclerosis (MS). The project will use computer modelling to simulate the movements involved in upper limb intention tremor, as exhibited by individuals with MS. The models will be incorporated into a final system that will interpret measurem...