Background: There is a direct correlation between ocular vascular endothelial growth factor (VEGF) level and progression of pathological outcomes in diabetic retinopathy. In our previous study, the periocular administration of propranolol and celecoxib could significantly reduce ocular VEGF levels in a diabetic mouse model. Here, we investigated the changes of serum VEGF after ...

Background DOX is a powerful chemotherapeutic agent used in the treatment of solid tumors and malignant hematological diseases. However, its cardiac toxicity limits the clinical usefulness of this drug. Previous reports have shown Corticosteroids induce a cytoprotective effect on cardiomyocytes. Mouse transgenic embryonic stem cell-derived pure cardiomyocytes may be considered as a model for a...

Neospora caninum (N. caninum) is an apicomplexan parasite and causes abortion and congenital neosporosis in cattle worldwide. In this study, we evaluate the virulence of a N. caninum isolate on mouse strain C57BL/6. Six groups of five mice C57BL/6 were intraperitoneally inoculated with 1 × l07, 1.5 × l07, 2 × l07, 3 × l07 and 4 × l07 tachyzoites and a control inoculum of DMEM, respectively. Cli...

In order to better understand the mechanical properties of biological cells, characterization and investigation of their material behavior is necessary. In this paper hyperelastic Neo-Hookean material is used to characterize the mechanical properties of mouse oocyte cell. It has been assumed that the cell behaves as continuous, isotropic, nonlinear and homogenous material for modeling. Then, by...

Background: Rodents with short reproductive cycle length are the best model for investigation of physiology and molecular aspects of reproductive biology. This study aimed to establish a correlation between histological changes of uterus and ovaries with the vaginal smear. Materials and Methods: 6-8 weeks old virgin Female NMRI mice were submitted to the vaginal smear collection and observed us...

background dox is a powerful chemotherapeutic agent used in the treatment of solid tumors and malignant hematological diseases. however, its cardiac toxicity limits the clinical usefulness of this drug. previous reports have shown corticosteroids induce a cytoprotective effect on cardiomyocytes. mouse transgenic embryonic stem cell-derived pure cardiomyocytes may be considered as a model for as...