نتایج جستجو برای: mir 103a 3p

تعداد نتایج: 49246  

Journal: :JCI insight 2017
Ali Hashemi Gheinani Bernhard Kiss Felix Moltzahn Irene Keller Rémy Bruggmann Hubert Rehrauer Catharine Aquino Fournier Fiona C Burkhard Katia Monastyrskaya

Bladder outlet obstruction (BOO) induces significant organ remodeling, leading to lower urinary tract symptoms accompanied by urodynamic changes in bladder function. Here, we report mRNA and miRNA transcriptome sequencing of bladder samples from human patients with different urodynamically defined states of BOO. Patients' miRNA and mRNA expression profiles correlated with urodynamic findings. V...

2016
Ana Flávia Teixeira Rossi Aline Cristina Targa Cadamuro Joice Matos Biselli‐Périco Kátia Ramos Moreira Leite Fábio Eduardo Severino Patricia P. Reis José Antonio Cordeiro Ana Elizabete Silva

Helicobacter pylori cause chronic inflammation favouring gastric carcinogenesis, and its eradication may prevent malignant transformation. We evaluated whether H. pylori infection and its eradication modify the expression of inflammatory mediators in patients with chronic gastritis. Furthermore, we assessed whether microRNAs modulate inflammatory pathways induced by H. pylori and identified miR...

2016
Zhenze Zhao Xiuye Ma Spencer D. Shelton Derek C. Sung Monica Li Daniel Hernandez Maggie Zhang Michael D. Losiewicz Yidong Chen Alexander Pertsemlidis Xiaojie Yu Yuanhang Liu Liqin Du

MYCN amplification is the most common genetic alteration in neuroblastoma and plays a critical role in neuroblastoma tumorigenesis. MYCN regulates neuroblastoma cell differentiation, which is one of the mechanisms underlying its oncogenic function. We recently identified a group of differentiation-inducing microRNAs. Given the demonstrated inter-regulation between MYCN and microRNAs, we specula...

2017
Tong Jiao Ye Yao Bo Zhang Da-Cheng Hao Qing-Feng Sun Jing-Bo Li Chao Yuan Bao Jing Yun-Peng Wang Hai-Yang Wang

MicroRNAs (miRNAs) are deregulated in various vascular ailments including abdominal aortic aneurysm (AAA). MiR-103 is involved in vascular, metabolic, and malignant diseases, but whether it participates in the pathogenesis of AAA remains elusive. ADAM10 plays a vital role in the formation of aneurysm, but whether miRs modulate its activity during AAA formation is totally unknown. In this study,...

Background: Chronic lymphocytic leukemia (CLL) is the most common adult human leukemia. Studies revealed that microRNAs (miRNAs) can function as oncogenes or tumor suppressors in CLL and that the expression of miRNAs, such as miR-193b-3p and miR-376a-3p change in several diseases. We aimed to elucidate the changes in miR-193b-3p and miR-376a-3p expression in CLL and determine their potential as...

2017
Jing Dong Ying-Zhi Liang Jie Zhang Li-Juan Wu Shuo Wang Qi Hua Yu-Xiang Yan

AIM To explore the relationship between lipometabolism-related microRNAs (miRNAs) in peripheral blood mononuclear cells (PBMCs) and the presence of coronary artery disease (CAD). METHODS In the present study, 161 stable CAD patients and 149 health controls were enrolled. The expression levels of seven miRNAs (miR-21, miR-24, miR-29a, miR-33a, miR-34a, miR-103a, and miR-122) in PBMCs were qual...

2016
Eliana Bignotti Stefano Calza Renata A. Tassi Laura Zanotti Elisabetta Bandiera Enrico Sartori Franco E. Odicino Antonella Ravaggi Paola Todeschini Chiara Romani

MicroRNAs (miRNAs) belong to a family of small non-coding RNAs (sncRNAs) playing important roles in human carcinogenesis. Multiple investigations reported miRNAs aberrantly expressed in several cancers, including high-grade serous ovarian carcinoma (HGS-OvCa). Quantitative PCR is widely used in studies investigating miRNA expression and the identification of reliable endogenous controls is cruc...

2015
Fengzhen Huang Zhe Long Zhao Chen Jiada Li Zhengmao Hu Rong Qiu Wei Zhuang Beisha Tang Kun Xia Hong Jiang Xiao-Jiang Li

Autism spectrum disorder (ASD) comprise a group of neurodevelopmental disorders characterized by deficits in social and communication capacities and repetitive behaviors. Increasing neuroscientific evidence indicates that the neuropathology of ASD is widespread and involves epigenetic regulation in the brain. Differentially expressed miRNAs in the peripheral blood from autism patients were iden...

Multiple sclerosis (MS) is an inflammatory disease that affects the central nervous system. MicroRNAs (miRNAs) are small non-coding RNAs that are usually 18-24 nucleotides long, which may have a pivotal role in the expansion of many complex diseases. The objective of this study was to evaluate the transcript levels of miR-193b-3p and miR-376a-3p in relapsing-remitting multiple sclerosis (RRMS) ...

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