A cytogenetic study was performed in lymphocytes of hospital workers occupationally exposed to X- and gamma-rays using the micronucleus centromere assay. A comparison of the data for the exposed group and an age-matched group of non-exposed hospital workers showed a significant (P < 0.05) increase in centromere-positive micronuclei for the radiation workers, while no effect on centromere-negati...

The micronucleus of Paramecium plays an essential role in the development of the oral apparatus in both asexual and sexual cycles. The present study analyses this somatic function of the micronucleus by interspecific transplantation of the micronucleus between two species, P. jenningsi and P. tetraurelia. The two species are similar in nucleogenesis in the sexual cycle, in the dependence of sto...

The development of the macronucleus from the zygotic micronucleus in the ciliated protozoan Tetrahymena spp. involves the elimination of specific DNA sequences (M. C. Yao and M. Gorovsky, Chromosoma 48:1-18 1974). The present study demonstrates that micronucleus-specific DNA is present on all five of the micronuclear chromosomes. Fragments of micronuclear DNA from Tetrahymena thermophila were c...

X-ray induced formation of micronuclei is generally thought to result from DNA double-strand breaks (DSBs). However, DNA DSBs inhibit the cell cycle progression that is required for micronucleus formation. In order to reconcile this apparent discrepancy, we investigated whether DNA DSBs induced during the G1 phase could lead to micronucleus formation. We irradiated human embryonic (HE17) cells ...

Galindo, T.P.S.; Rosário, I.R.; da Silva, E.M.; E. (2014) Micronucleus test in frillfin goby Bathygobius soporator (Valenciennes, 1873) from tide pools of Salvador city, Brazil. Braz. J. Aquat. Sci. Technol. 18(1):19-24. eISSN 19839057. DOI: 10.14210/bjast.v18n1.p19-24 The genotoxic effects of metals were evaluated in Bathygobius soporator using the micronucleus test. The frequencies of micronu...

A mutagenicity study was carried out in mice fed on a gamma-irradiated diet. As an indicator of mutagenic activity, we observed an incidence of micronuclei in erythrocytes. The average body weight of the mice fed on the diet irradiated to dose range of 400-1,000 kGy decreased, and the mice fed on the 800-1,000 kGy-irradiated diet died during the period from 8 to 14 days after the start of feedi...

The present study was aimed to investigate the frequency of micronuclei and other nuclear anomalies in alcoholic subjects. The present study included 100 subjects out of which 54 were alcoholics (23 smokers and 31 non smokers) and 46 subjects (non smokers) were healthy controls.The average age of alcoholics was of 44.185±4.434 years, very close to that of control individuals which was 41.281±6....

The aim of the letter to editor is to provide some comments regarding the manuscript of DehghanNezhad et al.(1) recently published in the Iranian Journal of Pathology titled “Micronucleus Assay of Buccal Mucosa Cells in Waterpipe (Hookah) Smokers: A Cytologic Study.” In this article, the authors were able to detect high frequencies of micronucleus in buccal mucosa cells of waterpipe smokers whe...

The genotoxic effect of the Austroplenckia populnea chloroform fraction from barkwood extract was tested in vivo on peripheral blood cells of Swiss mice with the comet assay (SCGE), and the clastogenic effect was investigated on peripheral blood cells of Swiss mice and bone marrow cells of Wistar rats, with the micronucleus and chromosome aberrations tests. The animals were treated by gavage wi...

Background and aim: Increased rate of micronucleus in buccal mucosa cells and its correlation with carcinogenesis is worth consideration. Recently, occupation in dental laboratories has been proposed as a predisposing factor. Therefore, the present study aimed to evaluate the effect of occupational exposure on buccal mucosa cells of dental laboratory technicians. Materials and methods: This ...