Electrical models for microelectrode-cell interfaces are essential to match electrical simulations to real biosystems performance and correctly to decode the results obtained experimentally. The accurate response simulation of a microelectrode sensor to changes in the cell-electrode system, such as cell growth, enables the optimum microelectrode design process. We report the use of COMSOL quasi...

—Determining neuronal structures during stereotactic surgery in Parkinson’s disease (PD) patients is a prerequisite for optimal placement of deep brain stimulation electrodes and/or neuronal ablation. This study describes statistical signal processing methods that automatically analyze microelectrode recordings and display a neurophysiological brainmap of the stereotactic trajectory. The sponta...

The reliability of two different membrane resistance-measuring methods that use a single intracellular microelectrode was tested against a conventional method that uses two intracellular microelectrodes. The first single-electrode method used a single square current pulse and required a constant microelectrode resistance. This method was unreliable because the electrode resistance changed marke...

BACKGROUND Microelectrode recording is an integral part of many surgical procedures for movement disorders. We evaluate the Lead point compared to the NeuroTrek system. We used NeuroTrek in 18 Parkinsonian patients, Lead point-4 in 12 patients, during STN-DBS surgery. We compared MR-Stir image with Microelectrode recording. METHOD The MicroGuide system with its integrated screen display provi...

These notes are intended to provide an introduction to the electronics of microelectrode and patch clamp amplifiers. How much electronics do you need to use a physiological amplifier? Enough to know how much distortion is introduced by the measurement. This means (1) testing the response to an input that simulates the physiological signal, (2) calibrating the gain and frequency response, and (3...

This study discusses the various procedures and issues involved in acquisition of microelectrode recordings (MER) signals subthalamic nucleus stimulations with induced deep brain stimulation electrodes very rigorously. Bellicose-invasive physiological detections through methods sub cortical physio logical detections, electrical micro electrode recordings, stereo-tactic technique, macro-stimulat...

INTRODUCTION Spinal cord injury (SCI) is a debilitating condition that affects over 250,000 people in the United States [1]. It results in paraplegia (paralysis of the lower limbs) or in tetraplegia (paralysis of the body below the neck) depending on where along the spinal column is affected [2]. It can result from either a physical injury to the head or spine or can be caused by a degenerative...

An equation for ionophoresis in large tip microelectrodes is derived from Nernst-Planck equations for the general case of a completely dissociated electrolyte. The relation between the release of ions and the applied electric current is mainly determined by two parameters: the transference number of the ions under consideration and the diffusional leak of the microelectrode. Also it is shown ho...