An encapsulated microbubble (EMB) of a novel construct is proposed to enhance the magnetic resonance imaging contrast by introducing superparamagnetic iron oxide (SPIO) nanoparticles (mean diameter is 12 nm) into the polymer shell of the microbubble. Such microbubble vesicle has nitrogen gas in the core and its mean diameter is 3.98 microm. An in vitro MR susceptibility experiment using a phant...

The introduction of microbubbles in focused ultrasound therapies has enabled a diverse range of non-invasive technologies: sonoporation to deliver drugs into cells, sonothrombolysis to dissolve blood clots, and blood-brain barrier opening to deliver drugs into the brain. Current methods for passively monitoring the microbubble dynamics responsible for these therapeutic effects can identify the ...

Focused ultrasound with microbubbles is being developed to transiently, locally and noninvasively open the blood-brain barrier (BBB) for improved pharmaceutical delivery. Prior work has demonstrated that, for a given concentration dose, microbubble size affects both the intravascular circulation persistence and extent of BBB opening. When matched to gas volume dose, however, the circulation hal...

Optofluidic manipulation mechanisms have been successfully applied to micro/nano-scale assembly and handling applications in biophysics, electronics, and photonics. Here, we extend the laser-based optofluidic microbubble manipulation technique to achieve hybrid integration of compound semiconductor microdisk lasers on the silicon photonic circuit platform. The microscale compound semiconductor ...

OBJECTIVE The combination of intracoronary transplantation and ultrasound-mediated microbubble destruction may promote effective and accurate delivery of bone marrow stem cells (BMSCs) into the infarct zone. To test this hypothesis in this study we examined the effectiveness of ultrasound-mediated microbubble destruction in combination with intracoronary transplantation of BMSCs for the treatme...

OBJECTIVE To evaluate whether microbubble-enhanced ultrasound (US) treatment promotes the delivery of methotrexate (MTX) into synovial cells and the enhanced antiinflammatory effects of intraarticular MTX therapy in a rabbit arthritis model. METHODS Arthritis was induced in both knees of 53 rabbits by immunization with ovalbumin. MTX including a microbubble agent was then injected into the le...

Citation: Pandhal J, Siswanto A, Kuvshinov D, Zimmerman WB, Lawton L and Edwards C (2018) Cell Lysis and Detoxification of Cyanotoxins Using a Novel Combination of Microbubble Generation and Plasma Microreactor Technology for Ozonation. Front. Microbiol. 9:678. doi: 10.3389/fmicb.2018.00678 Cell Lysis and Detoxification of Cyanotoxins Using a Novel Combination of Microbubble Generation and Plas...

We develop a method for fabricating very small silica microbubbles having a micrometer-order wall thickness and demonstrate the first optical microbubble resonator. Our method is based on blowing a microbubble using stable radiative CO(2) laser heating rather than unstable convective heating in a flame or furnace. Microbubbles are created along a microcapillary and are naturally opened to the i...

Gas-filled microbubbles have the potential to become a unique intravascular MR contrast agent due to their magnetic susceptibility effect, biocompatibility, and localized manipulation via ultrasound cavitation. However, microbubble susceptibility effect is relatively weak when compared with other intravascular MR susceptibility contrast agents. In this study, enhancement of microbubble suscepti...

Microbubble technologies have recently gained acceptance as radiological molecular imaging or perfusion agents. These intravenous ultrasound contrast agents consist of gasfilled microspheres stabilized by a ‘shell’ layer which interfaces with a surrounding solvent pool. Development in the form of encapsulation with complex biocompatible polymer shell consisting of proteins, lipids and surfactan...