Scintigraphy with Tc-99m dimercaptosuccinic acid (DMSA) is considered a reference method for assessment of parenchymal lesions and estimation of differential kidney function. The aim of study was to evaluate Tc-99m mercaptoacetyltriglycine (MAG3) dynamic renal scintigraphy for the same purpose. 188 patients, submitted to both studies within three months, were divided in two groups. In the first...

Received 2/18/2002; revised 3/4/2002; accepted 3/8/2002. For correspondence or reprints contact: Nan-Tsing Chiu, M.D., Department of Nuclear Medicine, National Cheng Kung University Hospital, 138 Sheng-Li Road, Tainan 704, Taiwan. Tel: (886)6-2353535 ext. 2480, Fax: (886)6-2766609, E mail: [email protected] Background: We conducted this study to explore the correlation of formula creatini...

UNLABELLED The expression of human telomerase reverse transcriptase (hTERT) is present in most malignant cells (>85%) but is undetectable in most normal somatic cells. Visualization of hTERT expression using radionuclide targeting can provide important diagnostic information in malignant tumors. The overall aim of this study was to evaluate whether (99m)Tc-radiolabeled antisense oligonucleotide...

Aim: To assess the outcomes of anatrophic nephrolithotomy in terms stone clearance and change renal function. Study design: Observational study Place duration study: Department Urology Sindh Institute & Transplantation, Karachi from 1st January 2016 to 31st December 2021. Methodology: Fifty patients who underwent were enrolled. Outcomes measured clearance, pre post procedure eGFR, serum cre...

Since its release for routine clinical use, (99m)Tc-mercaptoacetyltriglycine (MAG3) has become an important alternative to (131)I-labeled orthoiodohippuran. The cold kit for MAG3 is expensive, especially in developing countries. Therefore, unique storage conditions should be provided for cost reduction. Cold fractioning is a well-known procedure but has special requirements, such as a nitrogen ...

Background: Renal scintigraphy using Tc-mercaptoacetyltriglycine (Tc-MAG3) is widely used for the assessment of renal function in humans. However, the application of this method to animal models of renal disease is currently limited, especially in rodents. Here, we have applied Tc-MAG3 renal scintigraphy to a mouse model of unilateral ureteral obstruction (UUO) and evaluated its utility in stud...

Fabio P Esteves, MD: Department of Radiology, Division of Nuclear Medicine, Emory University Hospital, Atlanta, GA, 30322 Andrew Taylor, MD: Department of Radiology, Division of Nuclear Medicine, Emory University School of Medicine and Veterans Affairs Medical Center, Atlanta, GA,30322 Amita Manatunga, Ph.D. Department of Biostatistics, Emory University School of Medicine, Atlanta, GA, 30322 Ru...

Radionuclidic techniques may provide assessment of glomerular filtration rate (GFR) effective renal plasma flow (ERPF) or individual renal function. Several agents were available for determination of these parameters such as ¹³¹I-OIH (O-iodohippurate) and different derivatives of DADS (Diamidodisulfur). OIH has the disadvantage of imparting a relatively high absorbed radiation dose to the...

The epidermal growth factor receptor (EGFR) is overexpressed in many cancers, including breast, ovarian, endometrial and non-small cell lung cancer. An EGFR-specific imaging agent could facilitate clinical evaluation of primary tumors or metastases. To achieve this goal, 4-(2-aminoethylamino)-6,7-dimethoxyquinazoline (ADMQ) was synthesized based on a 4-aminoquinazoline core and then conjugated ...

BACKGROUND Experimental models are essential tools in the development and evaluation of novel treatment options, but the preclinical model of renal ischemia-reperfusion injury is limited to the retrieval of (very) early functional data, leaving the pivotal long-term outcome unknown. The present study applies technetium-99m-mercapto-acetyl-tri-glycine [99mTc-MAG3] scintigraphy for the longitudin...