نتایج جستجو برای: lingo

تعداد نتایج: 806  

Journal: :The Journal of biological chemistry 2009
Zhaohuan Zhang Xiaohui Xu Yong Zhang Jianfeng Zhou Zhongwang Yu Cheng He

LINGO-1 is a component of the tripartite receptor complexes, which act as a convergent mediator of the intracellular signaling in response to myelin-associated inhibitors and lead to collapse of growth cone and inhibition of neurite extension. Although the function of LINGO-1 has been intensively studied, its downstream signaling remains elusive. In the present study, a novel interaction betwee...

Journal: :Neuroscience and biobehavioral reviews 2015
Jessica L Andrews Francesca Fernandez-Enright

Leucine-rich repeat and immunoglobulin domain-containing protein (Lingo-1) is a potent negative regulator of neuron and oligodendrocyte survival, neurite extension, axon regeneration, oligodendrocyte differentiation, axonal myelination and functional recovery; all processes highly implicated in numerous brain-related functions. Although playing a major role in developmental brain functions, the...

2013
Zubair Ahmed Michael R. Douglas Gabrielle John Martin Berry Ann Logan

Axon regeneration in the injured adult CNS is reportedly inhibited by myelin-derived inhibitory molecules, after binding to a receptor complex comprised of the Nogo-66 receptor (NgR1) and two transmembrane co-receptors p75/TROY and LINGO-1. However, the post-injury expression pattern for LINGO-1 is inconsistent with its proposed function. We demonstrated that AMIGO3 levels were significantly hi...

2011
Ben Short

Retinoic acid keeps Lingo-1 quiet R etinoic acid (RA) promotes axon regeneration by silencing a key inhibitory receptor, Puttagunta et al. report. Neuronal regrowth after injury is limited, in part, by inhibitory proteins released upon disruption of the surrounding myelin sheath. These proteins bind to the Nogo receptor complex on the neuronal plasma membrane, thereby activating the RhoA GTPase...

Journal: :Materials Today 2005

Journal: :Revista da Anpoll 1998

Journal: :The American Journal of Psychology 1951

Journal: :The Journal of pharmacology and experimental therapeutics 2011
R Blake Pepinsky Zhaohui Shao Benxiu Ji Qin Wang Gym Meng Lee Walus Xinhua Lee Yinghui Hu Christilyn Graff Ellen Garber Werner Meier Sha Mi

LINGO-1 (leucine-rich repeat and Ig domain containing NOGO receptor interacting protein-1) is a negative regulator of myelination and repair of damaged axons in the central nervous system (CNS). Blocking LINGO-1 function leads to robust remyelination. The anti-LINGO-1 Li81 antibody is currently being evaluated in clinical trials for multiple sclerosis (MS) and is the first MS therapy that direc...

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