within 3 days after beginning DES treatment and develop a high proportion of malignant interstitial cell tumors when treated with the estrogen for periods of 7 months or longer. Comparable preparations were made from untreated animals of similar ages. The cyt RNA's were then tested for their ability to compete against RNA-3H synthesized on mouse DNA in vitro, using both "presaturation" and simu...

The effects of ovine interstitial cell-stimulating hormone (ICSH), ovine prolactin, or bovine growth hormone (BGH) on the growth and fine structure of transplantable Leydig cell tumors have been investigated. The Leydig cell tumor was capable of growth in the hypophysectomized mouse as well as in the intact mouse treated with rabbit antisera to ICSH. The ultrastructure of the Leydig cell was al...

Sertoli and Leydig cells, the two major somatic cell types in the testis, have different morphologies and functions. Both are essential for gonad development and spermatogenesis. However, whether these cells are derived from the same progenitor cells and the mechanism regulating the differentiation between these two cell types during gonad development remains unclear. A previous study showed th...

By means of immunocytochemical methods, immunoreactivity for the brain isoform of nitric oxide synthase (NOS-I) was recognized in numerous Leydig cells of the human testis as well as in MA-10 tumor and TM3 non-tumor mouse Leydig cell lines. Within the Leydig cell cytoplasm, immunocytochemical results suggested the occurrence of factors known to activate NOS-I such as glutamate and aspartate, as...

Sertoli-Leydig cells tumors are rare ovarian neoplasms that can be managed with conservative resection given their generally excellent prognosis. Here we report a case of Sertoli-Leydig cell tumor mistakenly diagnosed as an invasive mucinous adenocarcinoma at time of intraoperative consultation because of its blue-mucinous appearance in the frozen section material. The patient subsequently unde...

Leydig cell tumor is a rare benign which belongs to the category of sex cord stromal tumors ovary. usually presents with androgenizing features like hirsutism, deepening voice, or clitoromegaly and are often suspected only if such symptoms present. can however be estrogenizing non-functional. We report an incidental finding in patient who underwent hysterectomy for postmenopausal bleeding.

The immunohistochemical reaction to oncostatin M (OSM) was studied in normal human testes at different ages (fetuses, newborns, children, pubertal boys, adults, and elderly men), as well as in several testicular disorders including carcinoma-in-situ cells (CIS), germ cell tumors, benign functioning Leydig cell tumor, androgen insensitivity syndrome, Klinefelter's syndrome, and cryptorchidism. P...