نتایج جستجو برای: lassa fever

تعداد نتایج: 96729  

Journal: :Journal of virology 2013
Nadezhda E Yun Alexey V Seregin David H Walker Vsevolod L Popov Aida G Walker Jeanon N Smith Milagros Miller Juan C de la Torre Jennifer K Smith Viktoriya Borisevich Joseph N Fair Nadia Wauquier Donald S Grant Bayon Bockarie Dennis Bente Slobodan Paessler

Lassa fever (LF) is a potentially lethal human disease that is caused by the arenavirus Lassa virus (LASV). Annually, around 300,000 infections with up to 10,000 deaths occur in regions of Lassa fever endemicity in West Africa. Here we demonstrate that mice lacking a functional STAT1 pathway are highly susceptible to infection with LASV and develop lethal disease with pathology similar to that ...

2010
Érica Azevedo Costa Aline de Marco Viott Glauber de Souza Machado Maria Rosa Quaresma Bomfim Fabiana Magalhães Coelho Zélia Inês Portela Lobato Mauricio Resende Roberto Mauricio Carvalho Guedes

3. Centers for Disease Control and Prevention. Management of patients with suspected viral hemorrhagic fever. MMWR Morb Mortal Wkly Rep. 1988;37(Suppl 3):1–16. 4. Holmes GP, McCormick JB, Trock SC, Chase RA, Lewis SM, Mason CA, et al. Lassa fever in the United States. Investigation of a case and new guidelines for management. N Engl J Med. 1990;323:1120–3. DOI: 10.1056/NEJM199010183231607 5. Jo...

2015
Olayinka Stephen Ilesanmi Bridget Omotoso Faith Osaretin Alele Peter Adewuyi

Lassa fever is an acute, virulent viral haemorrhagic illness with high morbidity and mortality rates. Its awareness remains low in sub urban or rural community. This study was carried out to assess the awareness of Lassa fever of a rural community in the south western part of Nigeria. A descriptive cross sectional study of 122 respondents prior to a sensitization seminar on Lassa fever was carr...

Journal: :PLoS Medicine 2005
Thomas W Geisbert Steven Jones Elizabeth A Fritz Amy C Shurtleff Joan B Geisbert Ryan Liebscher Allen Grolla Ute Ströher Lisa Fernando Kathleen M Daddario Mary C Guttieri Bianca R Mothé Tom Larsen Lisa E Hensley Peter B Jahrling Heinz Feldmann

BACKGROUND Recent importation of Lassa fever into Germany, the Netherlands, the United Kingdom, and the United States by travelers on commercial airlines from Africa underscores the public health challenge of emerging viruses. Currently, there are no licensed vaccines for Lassa fever, and no experimental vaccine has completely protected nonhuman primates against a lethal challenge. METHODS AN...

Journal: :BMJ 1986

2016
Nafomon Sogoba Kyle Rosenke Jennifer Adjemian Sory Ibrahim Diawara Ousmane Maiga Moussa Keita Drissa Konaté Abdoul Salam Keita Ibrahim Sissoko Matt Boisen Diana Nelson Darin Oottamasathien Molly Millett Robert F. Garry Luis M. Branco Sékou F. Traoré Seydou Doumbia Heinz Feldmann David Safronetz

Lassa virus (LASV) is endemic to several nations in West Africa. In Mali, LASV was unknown until an exported case of Lassa fever was reported in 2009. Since that time, rodent surveys have found evidence of LASV-infected Mastomys natalensis rats in several communities in southern Mali, near the border with Côte d'Ivoire. Despite increased awareness, to date only a single case of Lassa fever has ...

Journal: :Ghana medical journal 2012
E K Dzotsi S-A Ohene F Asiedu-Bekoe J Amankwa B Sarkodie M Adjabeng A M Thouphique A Ofei J Oduro D Atitogo J H K Bonney S C N Paintsil W Ampofo

Lassa fever is a zoonotic disease endemic in West Africa but with no previous case reported in Ghana. We describe the first two laboratory confirmed cases of Lassa fever from the Ashanti Region of Ghana detected in October and December, 2011.

2013
David Safronetz Nafomon Sogoba Job E. Lopez Ousmane Maiga Eric Dahlstrom Marko Zivcec Friederike Feldmann Elaine Haddock Robert J. Fischer Jennifer M. Anderson Vincent J. Munster Luis Branco Robert Garry Stephen F. Porcella Tom G. Schwan Heinz Feldmann

BACKGROUND Lassa fever is an acute viral illness characterized by multi-organ failure and hemorrhagic manifestations. Lassa fever is most frequently diagnosed in Nigeria, Sierra Leone, Liberia, and Guinea, although sporadic cases have been recorded in other West African countries, including Mali. The etiological agent of Lassa fever is Lassa virus (LASV), an Arenavirus which is maintained in na...

2004
Daniel G. Bausch Sanie S.S. Sesay Babafemi Oshin

A niru Conteh spent 25 years in his native Sierra Leone dedicated to treating patients with Lassa fever, a rodentborne viral disease, to which he ultimately succumbed on April 4, 2004. Dr. Conteh's life is a model of the dedicated healthcare worker. His colleagues hope that his death can gal-vanize support for healthcare workers and scientists working on the front lines with Lassa fever virus a...

2015
David Safronetz Kyle Rosenke Jonna B. Westover Cynthia Martellaro Atsushi Okumura Yousuke Furuta Joan Geisbert Greg Saturday Takashi Komeno Thomas W. Geisbert Heinz Feldmann Brian B. Gowen

With up to 500,000 infections annually, Lassa virus (LASV), the cause of Lassa fever, is one of the most prevalent etiological agents of viral hemorrhagic fever (VHF) in humans. LASV is endemic in several West African countries with sporadic cases and prolonged outbreaks observed most commonly in Sierra Leone, Liberia, Guinea and Nigeria. Additionally several cases of Lassa fever have been impo...

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