نتایج جستجو برای: kif1b
تعداد نتایج: 71 فیلتر نتایج به سال:
Abstract Background Cholangiocarcinoma represents the second most common primary liver malignancy. The incidence rate has constantly increased over last decades. silent nature limits early diagnosis and prevents efficient treatment. Methods Immunoblotting immunohistochemistry were used to assess expression profiling of USP9X EGLN3 in cholangiocarcinoma patients. ShRNA was silence gene expressio...
A broad range of human malignancies is associated with nonrandom 1p36 deletions, suggesting the existence of tumor suppressors encoded in this region. Evidence for tumor-specific inactivation of 1p36 genes in the classic "two-hit" manner is scarce; however, many tumor suppressors do not require complete inactivation but contribute to tumorigenesis by partial impairment. We discuss recent data d...
DJ-1, the product of familial Parkinson's disease gene and an oncogene, is a cysteine protease which plays a role in anti-oxidative stress reaction. In this study, we identified the recognition sequence for DJ-1 protease by using recombinant DJ-1 and a peptide library. Protease activity of DJ-1 lacking C-terminal α-helix (DJ-1ΔH9) was stronger than that of full-sized DJ-1, and the most suscepti...
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