Intravenous lipopolysaccharide (LPS) leads to acute lung injury (ALI) in rats. The purpose of this study was to examine the anti-inflammatory and antioxidant efficacy of ketamine, propofol, and ketofol in a rat model of ALI. We induced ALI in rats via intravenous injection of LPS (15 mg kg(-1)). The animals were randomly separated into five groups: control, LPS only, LPS + ketamine (10 mg·kg(-1...

BACKGROUND/AIMS Different drug combinations are used for sedation in colonoscopy procedures. A ketamine-propofol (ketofol) mixture provides effective sedation and has minimal adverse effects. Alfentanil also provides anesthesia for short surgical procedures by incremental injection as an adjunct. However, no study has investigated the use of ketofol compared with an opioid-propofol combination ...

Abstract Background Ketofol is usually using as a sedative drug during painful procedures now. That Provides sedation, analgesia and rapid recovery. The aim of this study was to compare the efficacy, respiratory and hemodynamic profiles, and side effects of two various combination of ketamine and propofol in patients undergoing bone marrow aspiration (BMA) and lumbar puncture (LP). Materials...

Objectives: The aim of this work is to study the effects, adverse effects and recovery time of IV mixed propofol and ketamine (ketofol) in 3:1 ratio as a sedative analgesic in children with acute lymphoblastic leukemia undergoing bone marrow aspiration Methods: This was a prospective, observational pilot study of twenty patients; 3-12 years with ALL requiring sedation for BMA were included. Mix...

abstract background ketofol is usually using as a sedative drug during painful procedures now. that provides sedation, analgesia and rapid recovery. the aim of this study was to compare the efficacy, respiratory and hemodynamic profiles, and side effects of two various combination of ketamine and propofol in patients undergoing bone marrow aspiration (bma) and lumbar puncture (lp). materials an...

Objective: To evaluate the role of ketofol as induction agent in diabetic patients. Study Design: Randomized Control Trial. Setting: Department Anesthesia, Abwa Medical College, Faisalabad. Period: 01-12-21 to 01-05-22. Material & Methods: Patients after informed consent divided randomly into two groups 25 each. Group A receiving propofol 1.5 mg/kg and B 1:2 agent. The dose given was 1ml fo...

Patients with sleep apnea are prone to postoperative respiratory complications, requiring restriction of sedatives during perioperative care. We performed a prospective randomized study on 24 patients with obstructive sleep apnea (OSA) who underwent elective surgery under general anesthesia. The patients were equally divided into two groups: Group Dex: received dexmedetomidine loading dose 1 mc...

Background: Co-administration of anesthetics has been employed to decrease potential unpleasant effects associated with single drug. OBJECTIVES: This study was designed to evaluate the effects of co-administration of ketofol with diazepam or midazolam in healthy dogs. METHODS: Six adult mix-breed male dogs were used. After sedation with acepromazine (0.1 mg/kg), anesthesia was induced with kete...

background: ketamine increases blood pressure and heart rate. propofol is an anesthetic drug with rapid recovery, but it causes respiratory depression, low heart rate and low blood pressure. combination of ketamine and propofol provides sedation, analgesia, and rapid recovery with hemodynamic stability and minimal respiratory depression. there have been a few studies about the effect of differe...