The occurrence of jaundice in the newborn is so frequent and the theories put forward to explain it so various, that the following observations were made in the hope of throwing further light on the subject. Number of Infants Examined.?Over 300 infants (337) were studied. The total number was composed of two large series of consecutive births. No blood tests were made for syphilis, reliance bei...

An assessment was made of the value of: (i) the demonstration of intestinal alkaline phosphatase in plasma for the differentiation of intrahepatic from post-hepatic jaundice in 122 jaundiced patients; and (ii) the demonstration of an intermediate molecular mass gamma glutamyltransferase in plasma for the identification of post-hepatic cholestasis in 74 jaundiced patients. The first test had a d...

It has been claimed that gentamicin assays on the serum of jaundiced patients give falsely low levels and suggested that the antibiotic in such sera is bound to bile acids and thus is partly inactivated. No evidence of such inactivation has been obtained (i) in the serum of jaundiced patients treated with gentamicin, (ii) in sera with high bilirubin contents to which gentamicin was added, or (i...

Jaundiced babies undergoing phototherapy often develop diarrhoea. The cause of it is still uncertain. Increasing evidence supports a role of a secretory mechanism for the diarrhoea. We therefore studied the effects of bile from congenitally jaundiced rats undergoing phototherapy and of unconjugated bilirubin on rat small intestine in vivo and in vitro. Results suggest that: (1) the bile from ho...

Patients with obstructive jaundice have an increased incidence of peri-operative complications and immune dysfunction. This study was to investigate interleukin (IL)-12 (a cellular immunity stimulant), levels in jaundiced patients. 23 jaundiced patients and 17 controls were studied. There was significantly increased monocyte IL-12 production in jaundice, as measured by an ELISA, compared with t...

OBJECTIVE To evaluate the influence of cholestatic jaundice in weight variation. METHODS We used 64 adult rats divided into six groups: F1 (n = 6): normal females; F2 (n = 6): laparotomy females; F3 (n = 20): jaundiced females; M1 (n = 6): normal males; M2 (n = 6): laparotomy males; M3 (n = 20): jaundiced males. Jaundice was obtained by ligation and section of the biliopancreatic duct. The an...

BACKGROUND Management of hyperbilirubinemia remains a challenge for neonatal medicine because of the risk of neurological complications related to the toxicity of severe hyperbilirubinemia. OBJECTIVES The purpose of this study was to examine the validity of cord blood alkaline phosphatase level for predicting neonatal hyperbilirubinemia. PATIENTS AND METHODS Between October and December 201...