1. Papaverine, in the concentration range 50-150 microM, inhibited rhythmic spontaneous contraction and caused relaxation of KCl-induced contractures of rat ileal smooth muscle. 2. Spontaneous slow waves and spikes declined at low papaverine concentrations. 3. The normal 45Ca uptake of the ileum was reduced by papaverin. Although papaverine caused only a small inhibition of normal 45Ca efflux f...

Endotoxin causes gastrointestinal motility disorder. Aim of this study is to clarify inhibitory mechanisms of lipopolysaccharide (LPS) on smooth muscle contraction in rat ileum. Ileal tissues were isolated from control rat or from LPS-induced peritonitis model rat. Treatment with LPS inhibited carbachol (CCh)-mediated contraction in a time-dependent manner. Cyclooxygenase-2 (COX-2) and inducibl...

During the investigations of the effect of indoline-derivatives on the smooth muscle have been continued, we have discovered that 1-methyl-5-chloroindoline methylbromide (hereafter referred to as S-6) well contracts the isolated ileum of guinea pig. Thus, the mode of action of S-6 on the guinea pig ileum has been investigated under various con ditions. The aim of this paper is to show that S-6 ...

Bombesin-like peptides, which were identified from a diversity of amphibian skin secretions, have been demonstrated to possess several biological functions such as stimulation of smooth muscle contraction and regulation of food intake. Here, we report two novel bombesin-like peptides, bombesin-OS and bombesin-PE, which were isolated from Odorrana schmackeri and Pelophylax kl. esculentus, respec...

Previous studies indicate that Matricaria chamomilla (MC), a folk remedy plant, is very useful in the treatment of spasmogenic bowel diseases but the way of its action is not clear. For this purpose, we studied the effect of MC extract on the electrically activation in Guinea-Pig ileum in an invitro model. We used guinea pig in this study. After of kill, we brouhght out a piece of ileum and fix...

The plant Asparagus racemosus is used traditionally in Kenya for a variety of medicinal purposes including the management pain, asthma, and premature labour. However, dearth empirical studies means that there limited information on acute toxicity pharmacological effects to support these uses by local plant. aim this study was, therefore, evaluate toxicity, analgesic, smooth muscle relaxation aq...

The effect of chloroform soluble fraction (F-A) of twigs of Sarcostemma brevistigma on contractions induced by KCl, histamine, and acetylcholine in the isolated guinea pig ileum and taenia coli smooth muscles has been evaluated. F-A (19.5 microg/ml) significantly inhibited the contraction induced by 40 mM KCl to the extent of 87.6% in the isolated guinea pig ileum. In the isolated guinea pig il...