نتایج جستجو برای: ischemic tolerance

تعداد نتایج: 211039  

Journal: :Stroke 2009
Takao Urabe Hirotaka Watada Yasuyuki Okuma Ryota Tanaka Yuji Ueno Nobukazu Miyamoto Yasutaka Tanaka Nobutaka Hattori Ryuzo Kawamori

BACKGROUND AND PURPOSE The purpose was to assess the prevalence of disorders of glucose metabolism and insulin resistance in Japanese ischemic stroke patients with no history of diabetes by performing 75-gram oral glucose tolerance test (OGTT). METHODS We recruited 427 ischemic stroke patients (atherothrombotic infarction, n=220; lacunar infarction, n=125; cardioembolic infarction, n=82). OGT...

Journal: :Stroke 1999
M Weih K Kallenberg A Bergk U Dirnagl L Harms K D Wernecke K M Einhäupl

BACKGROUND AND PURPOSE Ischemic tolerance has been extensively studied in experimental models of heart and brain ischemia. While there is some clinical evidence of ischemic tolerance in the heart, it is not known whether the same is true for the human brain. METHODS We conducted a retrospective case-control study in 148 stroke patients with and without antecedent TIA. RESULTS Despite no sig...

Journal: :Stroke 2012
Roger P Simon Robert Meller An Zhou David Henshall

The approach to neuroprotection in stroke has relied mainly on exogenously administered drugs derived from research probing the cellular mechanisms of ischemic brain injury. This approach has had limited translational impact. Over 1000 putative neuroprotective agents have been developed, and over 100 agents have advanced to clinical trials. None, however, have shown clinical efficacy.1 By contr...

Journal: :Stroke 2008
Min Chen Ting-Jia Lu Xiao-Jing Chen Yang Zhou Qian Chen Xiao-Yan Feng Li Xu Wen-Hu Duan Zhi-Qi Xiong

BACKGROUND AND PURPOSE Activation of NMDA subtypes of glutamate receptors is implicated in cell damage induced by ischemia as well as for the establishment of ischemic tolerance after ischemic preconditioning in animal models. We investigated the contributions of NR2A- and NR2B-containing NMDA receptors to ischemic cell death and ischemic tolerance in a rat model of transient global ischemia. ...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2008
Robert Meller Simon John Thompson Theresa Ann Lusardi Andrea Nicole Ordonez Michelle Dawn Ashley Veronica Jessick Weihzen Wang Daniel John Torrey David Clifford Henshall Philip R Gafken Julie Anne Saugstad Zhi-Gang Xiong Roger Pancoast Simon

Ischemic tolerance is an endogenous neuroprotective mechanism in brain and other organs, whereby prior exposure to brief ischemia produces resilience to subsequent normally injurious ischemia. Although many molecular mechanisms mediate delayed (gene-mediated) ischemic tolerance, the mechanisms underlying rapid (protein synthesis-independent) ischemic tolerance are relatively unknown. Here we de...

Journal: :Glia 2005
Koichi Kawahara Tatsuro Kosugi Motoki Tanaka Takayuki Nakajima Takeshi Yamada

Sublethal ischemia leads to increased tolerance against subsequent prolonged cerebral ischemia in vivo. In the present study, we investigated the roles of the astrocytic glutamate (Glu) transporter GLT-1 in preconditioning (PC)-induced neuronal ischemic tolerance in cortical neuron/astrocyte co-cultures. Ischemia in vitro was simulated by subjecting cultures to both oxygen and glucose deprivati...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه فردوسی مشهد - دانشکده ادبیات و علوم انسانی دکتر علی شریعتی 1393

this study aimed at examining the effects of iranian efl learners’ anxiety, ambiguity tolerance, and gender on their preferences for corrective feedback (cf, henceforth). the effects were sought with regard to the necessity, frequency, and timing of cf, types of errors that need to be treated, types of cf, and choice of correctors. seventy-five iranian efl students, twenty-eight males and forty...

2016
Zhen Jin Jinzi Wu Liang-Jun Yan

It is well established that the brain can be prepared to resist or tolerate ischemic stroke injury, and mitochondrion is a major target for this tolerance. The preparation of ischemic stroke tolerance can be achieved by three major approaches: ischemic conditioning, hypoxic conditioning and chemical conditioning. In each conditioning approach, there are often two strategies that can be used to ...

Journal: :International journal of clinical and experimental medicine 2015
Zhiqiang Zhang Zhennan Li Chen Zou Jingjing Zhang Yi Zhu Yi Miao

BACKGROUND/AIMS Primary biliary cirrhosis (PBC), an autoimmune disease of the liver, is marked by slow progressive destruction of bile ducts. These patients with PBC often undergo orthotopic liver transplantation (OLT). Ischemic bile duct lesion (IBDL) is a major source of morbidity and even mortality after OLT. Cirrhosis of the liver has a higher tolerance to ischemia than a normal liver, but ...

Journal: :Pain medicine 2010
Qiqi Zhou Roger B Fillingim Joseph L Riley G Nicholas Verne

OBJECTIVE Mixed evidence exists regarding whether irritable bowel syndrome (IBS) patients show increased somatic pain perception compared with controls. The current study used a deep, tonic somatic pain stimulus (ischemic pain) to evaluate somatic hypersensitivity in IBS patients. METHODS A total of 27 diarrhea-predominant and 15 constipation-predominant IBS patients, and 29 controls particip...

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