Siderophores are small iron-binding molecules secreted by bacteria to scavenge iron. Mycobacterium tuberculosis (Mtb), the etiologic agent of tuberculosis, produces the siderophores mycobactin and carboxymycobactin. Complexes of the mycobacterial membrane proteins MmpS4 and MmpS5 with the transporters MmpL4 and MmpL5 are required for siderophore export and virulence in Mtb. Here we show that, s...

To determine if elemental carbonyl iron powder is safe and effective therapy for iron deficiency anemia, 20 nonanemic and 32 anemic volunteers were studied. Single doses of 1,000 to 10,000 mg of carbonyl iron (15 to 150 times the 65 mg of iron in the usual dose of ferrous sulfate) were tolerated by nonanemic volunteers with no evidence of toxicity and only minor gastrointestinal side effects. A...

1. Strontium absorption was studied in vivo with loops of ileum in rachitic chicks and found to be increased by vitamin D(3), bile salts and sodium lauryl sulphate. 2. Bile salts and sodium lauryl sulphate rendered strontium soluble in butanol-benzene (1:1, v/v). 3. Bile was not concerned in the absorption of iron in rats from its water-soluble form, ferrous sulphate. 4. Ligation of the bile du...

Nanostructured Iron Oxide with different morphologies of rod-like and granular have been suc-cessfully prepared via a solid-state reaction in the presence of NaCl, NaBr, NaI and NaN3, respectively. The added salts not only prevent a drastic increase in the size of the products but also provide suitable conditions for the oriented growth of primary nanoparticles. The formation mechanisms of thes...

A facile and sustainable protocol for synthesis of six different shaped iron oxides is developed. Notably, all the six shapes of iron oxides can be synthesised using exactly same synthetic protocol, by simply changing the precursor iron salts. Several of the synthesised shapes are not reported before. This novel protocol is relatively easy to implement and could contribute to overcome the chall...

There are reports that lead may promote free-radical initiated events in biological tissue. However, there are also reports on the inability of lead salts to stimulate the production of reactive oxygen species in isolated systems. Furthermore, there is no well understood rationale as to why lead should exhibit pronounced pro-oxidant properties. We are reporting that while lead acetate does not ...

Most of the problems of iron therapy which have troubled physicians during the past half century are fundamentally traceable to our ignorance of the mechanism by which iron is absorbed from the intestinal tract. Had that mechanism been understood, the discussions centering about the relative efficacy of inorganic and organic iron preparations would not have occurred, and hematologists would not...