VLA-1 (very late antigen-1) is implicated in recruitment, retention and activation of leukocytes and its blockade has been referred as a potential target of new drug discovery to address unmet medical needs in inflammatory disease area. In the present study, we investigate the effects of an anti-murine CD49a (integrin α subunit of VLA-1) monoclonal antibody (Ha31/8) on various experimental mode...

Pathological changes were seen in the lungs of ddY mice one week after repeated intraperitoneal injections of lipopolysaccharide (LPS) of Klebsiella pneumoniae. The infiltration of polymorphonuclear cells (PMN), mainly neutrophils, and lymphocytes into the alveolar septum, the infiltration of PMN into perivascular areas and microthrombi were recognized in this murine model. The blood levels of ...

Regulated recruitment and clearance of neutrophils (PMN) is the hallmark of competent host defense and resolution of inflammation. We now report that IFN-gamma controls PMN infiltration and modulates IL-6 signaling through its soluble receptor (sIL-6R) to promote their apoptosis and clearance. Induction of peritoneal inflammation in IFN-gamma-deficient (IFN-gamma-/-) mice emphasized that the in...

PURPOSE The current study aimed to elucidate the role of peritoneal fluid IL-17A in septic mice, and the effects of intraperitoneal or intravenous blockade of the IL-17A pathway by anti-IL17A antibody on survival, plasma, and peritoneal cavity cytokine profile in a murine caecal ligation and puncture (CLP) sepsis model. The main source of peritoneal fluid IL-17A in septic mice was identified. ...

burkitt's lymphoma is a lymphatic tumor classified as non-hodgkin lymphoma with small non cleaved cells. the disease has an incidence of two cases per million patients in north america, and usually present with an intra-abdominal tumor, or enlarged cervical lymph nodes. massive amounts of peritoneal and plural fluid is rarely seen in these patients. a three year-old girl presented with massive ...

Hepatic subcapsular steatosis is a rare and specific form of fatty change in the liver. It is a unique finding in diabetic patients receiving continuous ambulatory peritoneal dialysis (CAPD) and intraperitoneal insulin treatment. Intraperitoneal administration of insulin causes a unique pattern of fatty infiltration in the subcapsular location of the liver. Here we report a case of hepatic subc...

The purpose of this study is to describe CT and MR findings of early stage intraperitoneal rupture of hepatocellular Carcinoma (hCC). Nine patients (5 men, 4 women), with known hCC, displayed suspicious CT findings of early intraperitoneal rupture during routine follow up. These included a local fluid collection creating dentation on tumor surface, mimicing capsular retraction. Six of the patie...

Background and Aims. Intraperitoneal chemotherapy is a basic tool in the treatment of peritoneal malignancy. The purpose of the study is to investigate the effect of adjuvant perioperative intraperitoneal chemotherapy in the treatment of locally advanced colorectal cancer. Patients and Methods. Patients with T(3) and T(4) colorectal carcinomas that underwent R(0) resection received either hyper...

The present study was designed to investigate the histological lesions in lungs of white mice infected with Aspergillus fumigatus by intraperitoneal injection, nasal implantation, current research also examined an attempt treat these tissue using both antifungal Amphotericin B and alcoholic extract Trametes for two weeks. results showed that A. led changes represented degeneration, desquamation...