Primary intraocular lymphoma is almost always a central nervous system B-cell non-Hodgkin lymphoma. Primary intraocular lymphoma is commonly diagnosed by demonstrating lymphoma cells in the vitreous or cerebrospinal fluid. An interleukin (IL) 10 to IL-6 ratio greater than 1.0 in these fluids and the detection of immunoglobulin gene rearrangement are useful adjuncts in the diagnosis of primary i...

Human intraocular tumors and tumors derived from human tumor cell lines grown subcutaneously in the athymic nude mouse were scanned by diagnostic ultrasound. Radiofrequency scan data were converted to digital form and analyzed in the frequency domain. Characteristics of normalized power spectra were found to be significantly different among human spindle cell malignant melanomas, mixed/epitheli...

OBJECTIVE To describe the clinical and histopathologic features of noncontiguous tumor recurrence after transscleral local resection of posterior uveal melanoma. METHODS Chart review was performed to identify patients with noncontiguous tumor recurrences from a series of 494 consecutive patients treated with transscleral local resection for uveal melanoma. The clinical and histopathologic fea...

Purpose To report an innovative new treatment option for ciliary body tumor metastasis from renal cell carcinoma treated with intravitreal bevacizumab. Observations A 70-year-old Caucasian man presented with a ciliary body tumor as a result from metastasis from renal cell carcinoma. It was preferable to treat the ciliary body tumor in the least invasive manner possible based on the patient's ...

PURPOSE To determine the safety of pars plana vitrectomy in eyes containing a treated posterior uveal melanoma. DESIGN Interventional case series. METHODS Retrospective case series of patients with posterior uveal melanoma who underwent pars plana vitrectomy. Complications, vitreous cytology, local tumor control, and metastasis were assessed. RESULTS Nine patients met study criteria. Tumo...

Introduction: Ophthalmic plaque radiotherapy using I-125 radioactive seeds in removable episcleral plaques is often used in management of ophthalmic tumors. Radioactive seeds are fixed in a gold bowl-shaped plaque and the plaque is sutured to the scleral surface corresponding to the base of the intraocular tumor. This treatment allows for a localized radiation dose delivery to the tumor with a ...

Macrophages are part of the tumor microenvironment and have been associated with poor prognosis in uveal melanoma. We determined the presence of macrophages and their differentiation status in a murine intraocular melanoma model. Inoculation of B16F10 cells into the anterior chamber of the eye resulted in rapid tumor outgrowth. Strikingly, in aged mice, tumor progression depended on the presenc...

PURPOSE To establish human retinoblastoma (RB) animal models that allow sensitive, noninvasive and continuous monitoring of tumor growth and metastasis in vivo. METHODS The human RB tumor cell lines HXO-Rb44 and Y79 were engineered to express a fusion reporter gene allowing for bioluminescence and fluorescence imaging. Intraocular and metastatic tumors were induced in immunodeficient nude mic...

Intraocular medulloepithelioma of cilliary body is a nonhereditary neoplasm childhood arising from primitive medullary epithelium characterized by cords multi-layered neuroepithelial cells resembling the optic cup. It often present as loss vision, painful eye & leucocoria. Common signs include secondary glaucoma dislocated lens. About half patients undergo surgery before discovery this tumo...