Topical propranolol has been used in clinics for treating cutaneous infantile haemangiomas, but frequent applications of semi-solid preparations are required to maintain therapeutic drug concentrations the skin layers over time. This work aims study preparation patches by hot-melt ram extrusion printing, a novel technique suitable personalization dosage forms. The steps are: i) mixing poly-ammo...

Article type: Review Article Infantile Haemangiomas (IH) are the most common vascular tumors occurring in early childhood, with a prevalence of approximately 510% of infants. These vascular tumors are divided into two main groups including; infantile haemangioma and vascular malformations. Although, haemangioma of infancy are common, benign and selflimited tumors, a significant percent of these...

Infantile hemangiomas, also known as ‘’haemangiomas of infancy,’’ (IHs) are common benign tumors of endothelial cells characterized by a unique pattern of rapid proliferation that occurs in the first months of life, followed by slow involution that may take years to complete. They reportedly occur in as many as 12% of children and are frequently brought to the attention of plastic surgeons, der...

In a letter to the editor, Léauté-Labrèze and colleagues describe the chance observation of the significant beneficial effects of propranolol on infantile haemangiomas (IH). A child, aged four months, had a large nasal IH, which had not responded to standard treatment with oral prednisolone (3 mg/kg/day). Coincidentally, the infant developed hypertrophic obstructive cardiomyopathy and was comme...