Clindamycin resistance in Staphylococcus species can be either constitutive or inducible. Inducible resistance cannot be detected by the conventional antimicrobial susceptibility test. In this study, we determined the prevalence of inducible clindamycin resistance in staphylococcal isolates at a Korean tertiary care hospital. Between February and September 2004, 1,519 isolates of Staphylococcus...

Background: Antibiotics called macrolide, lincosamide and streptogramin B (MLSB) are being used to treat staphylococci infections. Multiple pathways that impart resistance to MLSB antibiotics have been confirmed to cause clinical failure. The present work aimed to determine the frequency of constitutive and inducible clindamycin resistant among coagulase-negative staphylococci (CoNS) isolates o...

BACKGROUND Clindamycin is a frequently used antimicrobial therapeutic medicine used for the treatment of skin and soft tissue infections caused by Staphylococcus aureus strains. Resistance to this antibiotic is either constitutive or inducible. Constitutive resistance to clindamycin could be detected by standard susceptibility testing methods. Inducible clindamycin resistance could not be detec...

Inducible clindamycin resistance in Staphylococcus aureus is of great concern owing to its frequent association with false sensitivity in antibiogram and treatment failure. One hundred and two clinical isolates of Methicillin resistant S. aureus (MRSA) were identified by oxacillin, cefoxitin disc diffusion and oxacillin agar dilution method. Antibiotic susceptibility to erythromycin and clindam...

Increasing frequency of methicillin resistant Staphylococcus aureus (MRSA) infections and changing patterns in antimicrobial resistance have led to renewed interest in the use of macrolide-lincosamide-streptogramin (MLS) antibiotics to treat such infections. Inducible macrolides, lincosamides, type B streptogramins (MLS(Bi)) resistance has to be identified to avoid clinical failure of clindamyc...

Introduction: Clindamycin is considered an useful alternate drug in penicillin-allergic patients in the treatment of skin & soft tissue infections caused by Staphylococcus aureus. Staphylococcus spp. can be resistant to erythromycin through either erm or msr A genes. Strains with erm-mediated erythromycin resistance may possess inducible clindamycin resistance but may appear susceptible to clin...

9 Clindamycin is increasingly used to treat canine pyoderma. Eight of 608 Staphylococcus 10 pseudintermedius isolates were positive for inducible clindamycin resistance by D-test and PCR 11 detection of ermB. Staphylococcus pseudintermedius isolates that are erythromycin-resistant but 12 clindamycin-susceptible by in vitro antimicrobial susceptibility testing should be tested for 13 inducible c...

Empirical treatment options for staphylococcal infections have become limited, as the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) strains have increased. Clindamycin has been a useful option for treating skin and soft-tissue infections caused by MRSA. However, expression of inducible macrolide-lincosamide-streptogramin B resistance (MLS(B)i) to clindamycin could limit the e...

We evaluated the accuracy of an erythromycin-clindamycin double-disk test (D-zone test) and an erythromycin-telithromycin D-zone test for detection of inducible resistance in isolates of beta-hemolytic streptococci with erythromycin resistance. The results of these tests were compared to results of a broth microdilution (BMD) induction test using combinations of erythromycin and either clindamy...

Clindamycin is increasingly used to treat canine pyoderma. Eight of 608 Staphylococcus pseudintermedius isolates were positive for inducible clindamycin resistance by double-disk diffusion testing and PCR detection of ermB. Staphylococcus pseudintermedius isolates that are erythromycin resistant but clindamycin susceptible by in vitro antimicrobial susceptibility testing should be tested for in...