background and objectives: with increasing rate of immunodeficiency diseases in the world, opportunistic micro-organism such as pneumocystis jirovecii ( p. jirovecii ) become more important. little information is available on prevalence of this life- threatening microorganism in iran. this study was designed to determine the colonization and the rate of active disease caused by p. jirovecii in ...

In This Issue In This Issue Toxic apoptosis antel et al. report that ␣-toxin from Staphylococcus aureus can induce apoptosis in immune cells (page 637). This may help the bacterium to immunosuppress the victim and continue proliferating. S. aureus was known to induce apoptosis, but the underlying mechanism was unknown. Bantel et al. find that the inducer is soluble. B Apoptosis can be triggered...

In Brazil, a high prevalence of cytomegalovirus (CMV) infection has been documented. In immunocompetent adults CMV infection is usually asymptomatic and therefore morphologic and immunophenotypic bone marrow changes have rarely been described. The authors report the case of a previously healthy patient who developed fever of undetermined origin. The diagnosis of acute CMV infection was based on...

This year approximately 20,000 individuals will receive an allogeneic hematopoietic cell transplant (HCT) as treatment for a malignant, or life-threatening non-malignant, hematopoietic disease. The process of HCT generally begins with administration of a preparative regimen to eradicate the underlying disease and immunosuppress the patient in order to prevent rejection of the subsequently trans...

R esearch and clinical trials aimed at prolonging allograft survival have historically been viewed as promoting either immunosuppression or tolerance. However, new studies reveal that some immunosuppressive agents may also promote tolerance through enhanced generation of regulatory T cells (Treg). These findings lead to new ways of thinking about these agents and how they might be combined to p...

A significant proportion of children with JIA-associated uveitis continue to develop considerable visual complications secondary to uveitis despite progress in establishing screening programmes in most countries [1 4]. The question that remains unanswered is why is there a reluctance to immunosuppress patients with active and potentially sight-threatening uveitis? The answer may be a lack of ro...

TRANSFUSION1993—Vol. 33, No, 5FACTOR CONCENTRATES 1992433 12. Finlayson JS, Tankersley DL, Anti-HCV screening and plasmafractionation: the ease against (letter). Lancct 1990;335:1274-5.13. Pneumocystis carina pneumonia among persons with hemophiliaA . MMWR Morb Mortal Wkly Rep 1982;31:365-7.14. Krciss JK, Kitchen LW, Princc HE, Kasper CK, Essex M . An­tibody to h...