A previous study showed that cocaine self-administration induced dopamine-independent reinforcing effects of s agonists mediated by their selective actions at s1 receptors (s1Rs), which are intracellularly mobile chaperone proteins implicated in abuserelated effects of stimulants. The present study assessed whether the induction was specific to self-administration of cocaine. Rats were trained ...

A previous study showed that cocaine self-administration induced dopamine-independent reinforcing effects of σ agonists mediated by their selective actions at σ1 receptors (σ1Rs), which are intracellularly mobile chaperone proteins implicated in abuse-related effects of stimulants. The present study assessed whether the induction was specific to self-administration of cocaine. Rats were trained...

Opiate testing is one of the most frequently requested assays in the death investigation of suspected drug overdoses. Screening assays typically target morphine, whereas more specific assays are able to positively identify and quantitate the particular opiate present in the specimen. Because many opiates are metabolized to morphine, it is often desirable to differentiate heroin-related deaths f...

background: opioid peptides and their receptors are present in the majority of body tissues including gastrointestinal tract.  heroin is one of the opioid derivatives that abuse increasingly today.  so far, there is no study on the effect of acute heroin administration on gastric acid and pepsin secretion.   objective:  to define the effect of the acute heroin consumption on basal and vagal-sti...

a mixture of acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride is used for the symptomatic treatment of common cold. in this study, a derivative spectrophotometric method based on zero-crossing technique was proposed for simultaneous determination of acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride. determination of these drugs was perf...

BACKGROUND This paper describes injection risk in an out-of-treatment population of young heroin users in Hanoi, Vietnam, including use of a soft-tissue portal known as a "cay ma" (injection sac). METHODS Data from a large cross-sectional survey (N=1270) are used to describe the prevalence of this practice and its association with disease. Additionally, data from an ethnographic substudy on i...

Sir, In Asia, Illicit opium and cannabis are produced mainly in Afghanistan, which makes major social and health problems for some countries, particularly Iran as the neighborhood. [1] In Iran, opium and hashish have been used for near 300 years, [2] but other drugs such as heroin, buprenorphine, cocaine, tramadol, and ecstasy are new drugs of abuse in this country. [3-6] Abuses of the new drug...

A search of the Home Office index of notified drug addicts identified 1499 deaths during 1967-81, of which 226 (15%) were of therapeutic addicts--that is, patients who had become addicted during medical treatment with a notifiable drug--and 1273 (85%) were of non-therapeutic addicts. The crude mortality fell from 23.5/1000/year for the period 1968-70 to 18.4/1000/year for 1978-80. Altogether 41...

This paper discusses intersections of public health research and criminal justice research on the topic of drugs and crime. The drugs of interest mainly are marijuana, heroin, and other internationally regulated compounds of illegal origin, and such internationally regulated products of legal origin as pharmaceutical cocaine hydrochloride, codeine, and oxycodone, which also may be consumed on a...