BACKGROUND Although previous studies have demonstrated the clinical benefits of dalfampridine extended release (D-ER) tablets in patients with multiple sclerosis (MS), there are limited real-world data on D-ER utilization and associated outcomes in patients with MS. PURPOSE The objective of this study was to evaluate treatment patterns, budget impact, and health care resource utilization (HRU...

Players repeatedly face a coordination problem in a dynamic global game. By choosing a risky action (invest) instead of waiting, players risk instantaneous losses as well as a loss of payoffs from future stages, in which they cannot participate if they go bankrupt. Thus, the total strategic risk associated with investment in a particular stage depends on the expected continuation payoff. High c...

The well-known access control model formalized by Harrison, Ruzzo, and Ullman (HRU) does not allow testing for absence of access rights in its commands. Sandhu's Typed Access Matrix (TAM) model, which introduces strong typing into the HRU model, continues this tradition. Ammann and Sandhu have recently proposed an extension of TAM called augmented TAM (ATAM), which allows testing for absence of...

BACKGROUND Skeletal-related events (SREs; pathologic fracture [PF], spinal cord compression and radiation or surgery to bone) are common complications of bone metastases or bone lesions and can impose a considerable burden on patients and healthcare systems. In this study, the healthcare resource utilisation (HRU) associated with PFs in patients with bone metastases or lesions secondary to soli...

The well-known access control model formalized by Harrison, Ruzzo, and Ullman (HRU) does not allow testing for absence of access rights in its commands. Sandhu's Typed Access Matrix (TAM) model, which introduces strong typing into the HRU model, continues this tradition. Ammann and Sandhu have recently proposed an extension of TAM called augmented TAM (ATAM), which allows testing for absence of...

BACKGROUND Patients with fibromyalgia report persistent widespread pain, fatigue, and substantial functional limitations, which may lead to high health resource use (HRU) and lost productivity. Previous analyses of the U.S. population have not examined the direct and indirect costs of fibromyalgia by severity level. OBJECTIVES To assess (a) HRU, direct and indirect costs associated with fibro...

BACKGROUND The study aimed to evaluate health care resource utilization (HRU) and costs for neuropathic pain (NeP) secondary to spinal cord injury (SCI) among Medicaid beneficiaries. METHODS The retrospective longitudinal cohort study used Medicaid beneficiary claims with SCI and evidence of NeP (SCI-NeP cohort) matched with a cohort without NeP (SCI-only cohort). Patients had continuous Medi...

OBJECTIVE To compare healthcare resource utilization (HRU) and clinical decision-making for elderly patients based on cytochrome P450 (CYP) pharmacogenetic testing and the use of a comprehensive medication management clinical decision support tool (CDST), to a cohort of similar non-tested patients. METHODS An observational study compared a prospective cohort of patients ≥65 years subjected to...

BACKGROUND Accurate tracking of the administered dose of asthma rescue inhalers is critical for optimal disease management and is related to reductions in rates of unscheduled health care utilization in asthma patients. There are few published data on the real-world impact of rescue inhalers with integrated dose counters (IDCs) on health care resource utilization (HRU) for asthma patients. This...

BACKGROUND Neurogenic detrusor overactivity (NDO) leads to impaired health-related quality of life (HRQoL), productivity, and greater healthcare resource burden. The humanistic and economic burden may be more apparent in NDO patients with urinary incontinence (UI). The objective of this study was to compare the HRQoL, productivity, and health resource use (HRU) between continent and incontinent...