the human leukocyte antigen has become a key component in investigating the genetic relationships between populations. the aim of this study was to determine the genetic diversity of hla class i and ii alleles among zaboli ethnic group of south-east iran to establish a database for further investigations on ancestry and the genetic factors contributing to complex diseases in this region. unrela...

background: different studies have demonstrated that a small proportion of healthy individuals receiving the hepatitis b (hb) vaccine do not produce protective levels of anti-hb antibody, a phenomenon which could be linked to certain human leukocyte an-tigen (hla) class-ii alleles or haplotypes. objectives: the present study was under-taken to determine the frequency of hla class-ii alleles in ...

background: human t cell lymphotropic virus type i (htlv-i)-associated myelopa-thy/tropical spastic paraparesis (ham/tsp) is an inflammatory disease which occurs in less than 2% of htlv-i -infected individuals. high proviral load, high htlv-i-specific cd8+ cytotoxic t lymphocyte frequency (ctl) and host genetic factors such as hla all appear to be associated with htlv-i infection. previous stud...

the major histocompatibility complex (mhc) genes are the most polymorphic loci in the human genome and have been widely studied in various populations and ethnic groups. investigations into the hla genes and proteins have been useful tool for anthropological, transplantation and disease association studies. the polymorphism of the hla class i (a, b, c) and class ii (drb1, dqa1, dqb1) genes were...

Background: Hepatitis B is an important infectious disease.  Since several years ago, mass vaccination against this viral infection has become as part of routine vaccination schedule of Iran.  However, some healthy neonates, children and adults fail to generate a protective antibody response after vaccination.Objectives: To investigate distribution of HLA class-I and class-II antigens in health...

background: pediatric bronchial asthma is associated with considerable morbidity. the study was carried out to examine the association of human leukocyte antigen (hla)- class ii with the disease as we found no similar study on asian indian population. objective: to define the hla-class ii antigens in asian indian pediatric patients with asthma. methods: a total of 103 children with asthma and 1...

Background: Human leukocyte antigen (HLA) class II has shown potential in determining prognosis, understanding medication reactions, and predicting onset of Graves’ disease. The aim this study is to further investigate the association between disease HLA II, specifically HLA-DQ HLA-DR, via meta-analysis find HLAs that can be examined for prognostic reasons.

Autoimmune hepatitis (AIH) can arise de novo after liver transplantation (LT) for non-autoimmune liver diseases. Considering the identical features of de novo AIH after LT and classical AIH, as well as the importance of anti-human leukocyte antigen (HLA) antibodies in graft rejection, we investigated the presence of circulating anti-HLA class II antibodies in the sera of 35 patients with AIH, 3...

Major histocompatibility complex (MHC) class II-positive cell lines which lack HLA-DM expression accumulate class II molecules associated with residual invariant (I) chain fragments (class II-associated invariant chain peptides [CLIP]). In vitro, HLA-DM catalyzes CLIP dissociation from class II-CLIP complexes, promoting binding of antigenic peptides. Here the physical interaction of HLA-DM with...

Ulcerative colitis (UC) is a nonspecific acute and chronic inflammatory bowel disease that diffusely involves the colonic mucosa. The etiology of UC has not yet been elucidated fully. However, many studies have found that immunologic disorders may play a role in the pathogenesis of UC. In addition, due to an increased frequency of UC in families, especially an increased monozygotic compared...