INTRODUCTION Numerous herbal medicines have been recommended for the treatment of different diseases. Achyranthes aspera, Linn. (Family: Amaranthaceae), popularly known as Charchitta or Pitpapra, is commonly used by traditional healers for the treatment of fever, malaria, dysentery, asthma, arterial hypertension, pneumonia, and diabetes. The root extract is well reputed for its insect molting h...

The present study was undertaken to evaluate antioxidant and hypolipidemic activity of Vedic guard, a polyherbal formulation comprising of Terminalia arjuna, Withania sominefera, Bacopa monnierii, Tinosporia cardifolia, Commiphora mukul and many other plant extracts, all of which are classifieds in Ayurveda as Rasaayanas which are reported to promote antioxidant and hypolipidemic activity. Anti...

purpose: to evaluate the association between hyperlipidemia with severity of diabetic retinopathy in patients with type i diabetes mellitus referred to the eye clinic at imam khomeini hospital, ahvaz, iran. methods: this observational cross-sectional study included 52 patients with type i diabetes mellitus. fasting blood samples for analysis of serum lipids and hba1c were obtained from all pati...

Correspondence Older age was a risk factor for hepatotoxicity in adults, 2 , 4 whereas smaller children were reported to be under risk 5 in childhood. However, our study did not demonstrate any age-specifi c difference for hepatotoxicity. In conclusion, severe hepatotoxicity in children was found to be lower than reported before, and age did not affect the incidence of INH hepatotoxicity, as it...

INTRODUCTION The prevalence and risk factors for rifampin, isoniazid and pyrazinamide hepatotoxicity were evaluated in HIV-infected subjects and controls. METHODS Patients with tuberculosis (30 HIV positive and 132 HIV negative), aged between 18 and 80 years-old, admitted to hospital in Brazil, from 2005 to 2007, were selected for this investigation. Three definitions of hepatotoxicity were u...

BACKGROUND Imatinib can induce severe hepatotoxicity, in 1-5% of CML patients, many of whom need permanent imatinib discontinuation. DESIGN AND RESULTS We report 5 CML patients who developed grade 3-4 hepatotoxicity after 2-8 months in imatinib. Different aetiologies of liver damage were ruled out and toxicity recurred in 2 patients with further attempts at low dose imatinib. In all patients ...

INTRODUCTION There are few reports summarizing the effectiveness of oral and intravenous (IV) acetylcysteine. We determined the proportion of acetaminophen poisoned patients who develop hepatotoxicity (serum transaminase > 1000 IU/L) when treated with oral and IV acetylcysteine. METHODS Studies were double abstracted by trained researchers. We determined the proportions of patients who develo...

Relatively little is known about the hepatotoxicity of pyrazinamide (PZA). PZA requires activation by amidase to form pyrazinoic acid (PA). Xanthine oxidase then hydroxylates PA to form 5-hydroxypyrazinoic acid (5-OH-PA). PZA can also be directly oxidized to form 5-OH-PZA. Before this study, it was unclear which metabolic pathway or PZA metabolites led to hepatotoxicity. This study determines w...

• Objective: To assess and compare practicing gastroenterologist and primary care physician (PCP) knowledge of risk factors for, clinical management of, and attitudes toward liver transplantation for acetaminophen hepatotoxicity. • Participants and setting: 333 PCPs and 64 gastroenterologists practicing in Michigan. • Outcome measures: Knowledge of risk factors and management were measured by s...