Abstract Background Acetaminophen overdose is the leading cause of acute liver injury (ALI) and failure (ALF) in developed world. We aimed at studying therapeutic potential bone marrow mesenchymal stem cells (MSCs) accelerating healing acetaminophen-induced hepatotoxicity. Results This prospective study included 50 male albino rats divided into 2 groups: hepatotoxic group non-hepatotoxic group....

Methylene dianiline (DDM) is a chemical intermediate in the production of isocyanates and other industrial chemicals, and it is hepatotoxic in humans. The acute hepatotoxicity of orally administered DDM was characterized in rats. Rats receiving DDM (25-225 mg/kg, per os) demonstrated a dose-dependent elevation in serum alanine aminotransferase activity, g-glutamyltransferase activity, and serum...